Aim and Objective: Ischemia modified albumin (IMA) is a biomarker that has been introduced
recently for use in the evaluation of oxidative stress. The aim of this study was to measure the ischemia
modified albumin serum levels in pediatric patients with diabetic ketoacidosis (DKA) during acidosis and
after the patient recovered from acidosis and to compare these with the control group.
Materials and Methods: Pediatric patients with Type I diabetes mellitus (T1DM) who were admitted
to the pediatric intensive care unit with the diabetic ketoacidosis were assigned as the study group and
healthy children who were admitted to the outpatient clinic and decided as healthy after clinic and
laboratory evaluation were selected as the control group. IMA and adjusted IMA levels were evaluated
in the blood samples from the control group and the study group when admitted first time to the
intensive care unit during the acidosis period (DKA before treatment, DKA-BT), and after recovering
from acidosis (DKA after treatment, DKA-AT).
Results: A total of 24 pediatric patients with diabetic ketoacidosis and 30 healthy control children
matching age and sex were included in the current study. The albumin levels in pediatric patients with
T1DM during DKA-BT were higher than the albumin levels after acidosis (4.101±0.373, 3.854±0.369
g/dL, respectively) (p<0.05). However, there was no significant difference when these values were
compared to the control group. Mean values of IMA and Adj-IMA were statistically higher in DKAAT
compared to the control group (0.748±0.150 vs 0.591±0.099, p< 0.001; 0.708±0.125 vs
0.607±0.824, p< 0.001, respectively). IMA and adjusted IMA levels measured after recovered from
acidosis were significantly higher compared to the level of IMA during DKA (0.748±0.150 vs
0.606±0.105 as absorbance unit, p<0.001; 0.708±0.125 vs 0.625±0.100, p<0.05, respectively).
Conclusion: In children with T1DM, even though acidosis recovered following the treatment in
diabetic ketoacidosis, which is an oxidative stress marker, the ischemia modified albumin levels and
adjusted ischemia modified albumin levels were high.