Background: Currently, a study on the relationship between candidiasis and cancer has been
conducted. Until recent years, the opportunistic fungus C. albicans is mainly associated with cancer
processes and is able to stimulate carcinogenesis and metastasis.
Methods: A number of ionic liquids as potential anticancer and anti-Candida agents have been investigated
based on modern theoretical and experimental data about the relationship between oncopathology
and candida infection.
Results: The analysis of the received experimental results demonstrates that ionic liquid with alkyl
chain length of 6 carbon atoms (C6) has not shown anti-Candida activity. The indicators of its cytotoxicity
ІС50 (28,617μМ) and MTC (9,050 μМ) against HEP-2 tumor cell line were also very low. Compounds
with alkyl chain length C12 have shown high potential of anti-Candida activity and anticancer
Conclusion: Based on the obtained results, сompound 4 (C12C1IM-Cl) is proposed for further study as a
potential double-acting agent with high anticancer and anti-Candida activities. N-myristoyltransferase is
presented and used for docking as a potential molecular target responsible for the dual anti-Сandidа and
anticancer activities of studied ionic liquids.