Synthesis, Molecular Docking, and In Vitro Investigation of 1,1'-Diaryl- 3,3'-(p-phenylenedicarbonyl) dithioureas as Urease Inhibitors

Author(s): Hummera Rafique*, Fizza Tahira, Syeda Zar Afshan, Muhammad Naseem, Naghmana Kausar, Aamer Saeed, Muhammad Sharif.

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 4 , 2020

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Abstract:

Synthesis of some 1,1'-diaryl-3,3'-(p-phenylenedicarbonyl)dithioureas was accomplished in two steps. Dithioureas were prepared under inert conditions with significantly high yields. Inhibitory activity of dithiourea compounds was investigated against urease enzyme. All the synthesized compounds were evaluated for their urease inhibitory activities, and molecular docking studies were carried out to ascertain the inhibitor binding mode with the enzyme. All the compounds displayed moderate to significant urease inhibitory activities.

Keywords: Dithioureas, urease inhibition activities, molecular docking, enzymes, inhibitor binding mode, in vitro, investigation.

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Article Details

VOLUME: 17
ISSUE: 4
Year: 2020
Page: [254 - 259]
Pages: 6
DOI: 10.2174/1570178616666191004111058
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