Background: Schistosomiasis (snail fever/bilharzia), a disease caused by parasitic flatworms
(schistosomes), infects millions of people worldwide. Aquaporins from these organisms
were found to be a potent drug target.
Introduction: We investigate the possible mechanism of inhibition of Aquaporin (AQP) from
S.mansoni by 5 drug molecules (Praziquantel, Metrifonate, Artimisinin, Albendazole, and Amoscanate).
Methods: 3D molecular structure of Aquaporin was obtained through homology modeling and further
protein-ligand docking and MD simulation were performed.
Result: VAL-75, ASN-91, ALA-220, ASN-222, ARG-225 amino acids were found to play crucial
role in ligand binding. TRP-71 and other important residues play major role in hydrophobic interactions
stabilizing protein-ligand complexes.
Conclusion: We hope that this study (with the newly identified aquaporin target) will support the
development of structure and pharmacophore-based novel S.mansoni drugs to control and curb