One Pot Multicomponent Biginelli Reaction Employing Ionic Liquids as an Organocatalyst

Author(s): Tanveer M. Shaikh*, Sankaranarayanan Nagarajan, Elango Kandasamy*

Journal Name: Current Organocatalysis

Volume 7 , Issue 2 , 2020


DOI : 10.2174/2213337206666191001214521

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Graphical Abstract:


Abstract:

Introduction: The N-heterocyclic compounds have been extensively studied in pharmaceutical industries. Furthermore, syntheses of such compounds employing organo-catalyst have been associated with sustainable technology.

Methods: The synthesis of new, stable ionic liquids and their catalytic applications in one-pot multicomponent Biginelli reaction is presented. The method provides broad substrate scope, yielding the corresponding 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, in good to excellent yields, respectively.

Results and Conclusion: The developed reactions are associated with certain advantages, short reaction time and sustainable conditions. The protocol has advantages eco-friendly procedure, recovery and reusability of catalyst, which showed consistent activity.

Keywords: Biginelli reaction, multicomponent, Ionic liquid, organocatalyst, dihydropyrimidinones, dihydropyrimidinthiones.

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VOLUME: 7
ISSUE: 2
Year: 2020
Published on: 01 July, 2020
Page: [96 - 107]
Pages: 12
DOI: 10.2174/2213337206666191001214521

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