Title:Electrochemical Nano-biosensors as Novel Approach for the Detection of Lung Cancer-related MicroRNAs
VOLUME: 20 ISSUE: 1
Author(s):Roghayeh Sheervalilou, Omolbanin Shahraki, Leili Hasanifard, Milad Shirvaliloo, Sahar Mehranfar, Hajie Lotfi, Younes Pilehvar-Soltanahmadi, Zahra Bahmanpour, Sadaf Sarraf Zadeh, Ziba Nazarlou, Haleh Kangarlou, Habib Ghaznavi* and Nosratollah Zarghami*
Affiliation:Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Cellular and Molecular Research Center, Research Institute for Cellular and Molecular Medicine, Urmia University of Medical Sciences, Urmia, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Neurosciences Research Center, Shahid Beheshti University of Medical Science, Tehran, Material Engineering Department, College of Science Koç University, Istanbul 34450, Department of Physics, Urmia Branch, Islamic Azad University, Urmia, Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz
Keywords:Biomarker, Detection, Electrochemical, Lung Cancer, MicroRNA (miRNA), Nano-biosensor.
Abstract:In both men and women around the world, lung cancer accounts as the
principal cause of cancer-related death after breast cancer. Therefore, early detection of
the disease is a cardinal step in improving prognosis and survival of patients. Today, the
newly-defined microRNAs regulate about 30 to 60 percent of the gene expression.
Changes in microRNA Profiles are linked to numerous health conditions, making them
sophisticated biomarkers for timely, if not early, detection of cancer. Though evaluation
of microRNAs in real samples has proved to be rather challenging, which is largely
attributable to the unique characteristics of these molecules. Short length, sequence
similarity, and low concentration stand among the factors that define microRNAs.
Recently, diagnostic technologies with a focus on wide-scale point of care have recently
garnered attention as great candidates for early diagnosis of cancer. Electrochemical
nano-biosensors have recently garnered much attention as a molecular method,
showing great potential in terms of sensitivity, specificity and reproducibility, and last but
not least, adaptability to point-of-care testing. Application of nanoscale materials in
electrochemical devices as promising as it is, brings multiplexing potential for conducting
simultaneous evaluations on multiple cancer biomarkers. Thanks to their enthralling
properties, these materials can be used to improve the efficiency of cancer diagnostics,
offer more accurate predictions of prognosis, and monitor response to therapy in a more
efficacious way. This article presents a concise overview of recent advances in the
expeditiously evolving area of electrochemical biosensors for microRNA detection in
lung cancer.
