Endometrial cancer is the fifth leading cancer among women. This rate is higher in developed
countries and its incidence is increasing worldwide. Diabetes mellitus, obesity, hypertension and
arteriosclerosis are major risk factors for endometrial cancer. Melatonin is a hormone synthesized in
the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more. Evidence
shows the potential effects of melatonin in endometrial cancer inhibition. Therefore, the focus of this
paper is to review this outstanding evidence and to summarize the molecular and biological mechanisms
of melatonin for the inhibition of endometrial cancer.