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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Recent Updates on Antifungal Peptides

Author(s): Deepika Sharma and Gopal Singh Bisht*

Volume 20, Issue 4, 2020

Page: [260 - 268] Pages: 9

DOI: 10.2174/1389557519666190926112423

Price: $65

Abstract

The current trend of increment in the frequency of antifungal resistance has brought research into an era where new antifungal compounds with novel mechanisms of action are required. Natural antimicrobial peptides, which are ubiquitous components of innate immunity, represent their candidature for novel antifungal peptides. Various antifungal peptides have been isolated from different species ranging from small marine organisms to insects and from various other living species. Based on these peptides, various mimetics of antifungal peptides have also been synthesized using non-natural amino acids. Utilization of these antifungal peptides is somehow limited due to their toxic and unstable nature. This review discusses recent updates and future directions of antifungal peptides, for taking them to the shelf from the bench.

Keywords: Antifungal peptides, antimicrobial peptides, fungal infections, microbial resistance, marine organisms, living species.

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