In the current study, a green, one-pot, three-component reaction was performed to prepare
novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction
of a ketene S,S-acetal of Meldrum’s acid or barbituric acid (as key intermediates), hydrazine,
and isothiocyanate. The key advantages of this manner include environmentally safe reactions, high
yield, appropriate reaction time, simple reaction conditions, and use of a green reaction solvent. The
structure of thiadiazoles was determined based on the spectroscopic data.
Keywords: 5-amino-1, 3, 4-thiadiazole, Thiosemicarbazide, Ketene S, S-acetal, Meldrum’s acid, Barbituric acid, Deep Eutectic
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