Title:Depressed Serum 25-Hydroxyvitamin D Levels Increase Hospital Stay and Alter Glucose Homeostasis in First-ever Ischemic Stroke
VOLUME: 16 ISSUE: 4
Author(s):Yuge Wang, Yanqiang Wang, Bingjun Zhang, Yinyao Lin, Sha Tan and Zhengqi Lu*
Affiliation:Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Department of Neurology, The Affiliated Hospital of Wei Fang Medical University, Weifang, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou
Keywords:25-hydroxyvitamin D, first-ever ischemic stroke, hospital stay, functional outcome, mortality, vitamin D.
Abstract:
Background and Objective: Vitamin D deficiency is internationally recognized among
the potentially modifiable risk factors for ischemic cardio-cerebrovascular diseases. However, the
association between vitamin D deficiency and stroke morbidity or mortality remains insufficiently
known. Our aim is to investigate their relevance to 25-hydroxyvitamin D [25(OH) D] levels and
clinical severity and outcome after 3 months in first-ever ischemic stroke.
Methods: Retrospective analysis of 356 consecutive patients in first-ever ischemic stroke between
2013 and 2015. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at
admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome
after 3 months of onset was evaluated using the modified Rankin scale (mRS).
Results: Among the 356 enrolled patients, HbA1c was higher in insufficiency/deficiency group
than that in the sufficiency group (6.3 ± 1.7 vs. 5.9 ± 1.1, p =0.015). The hospital stay was longer
in insufficiency/deficiency group than that in the sufficiency group (11 (8-17) vs. 9.5 (7-13), p =
0.035). There was a significant inversed trend between serum 25(OH) D levels and hospital stay
(OR 0.960, P = 0.031), using logistic regression.
Conclusion: 25(OH)D levels are associated with glucose homeostasis, 25(OH) D contributes to
increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital
stay in first-ever ischemic stroke. Vitamin D deficiency did not predict functional outcome in
the span of 3 months.
