Development of Secondary Osteoporosis in Teenage Girls with Menstrual Disorders

Author(s): Elena V. Popova-Petrosyan, Shanmugaraj Kulanthaivel*, Keerthanaa Balasundaram

Journal Name: Current Women`s Health Reviews

Volume 16 , Issue 1 , 2020

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Introduction: Nowadays, the most common problem in teenage girls is them facing menstrual disorders that develop secondary osteoporosis in their adolescent period. The locomotor system disorder is noticed more often in girls with adolescence hormone pathology, than in the population. This has an enormous human and socio-economic impact. Osteoporosis is estimated to affect 200 million women worldwide.

Objective: The aim of this research is to determine the development of secondary osteoporosis in girls during their adolescent period.

Materials and Methods: An analysis of 173 girls aged from 13 to 17 were under our supervision in the children’s clinic sanatorium “Zdravnisa”. Girls were divided into four groups according to their menstrual disorders.

Results: As per the correlation analysis data, the influence of steroid hormones level on bone content has a cumulative effect on girls.

Conclusions: For patients with oligomenorrhea, secondary amenorrhea, and polymenorrhea, there were disordered correlations of gonadotropic hormones. Correlations between calcium, phosphorus, and magnesium are disordered, which can be proof of mineralization processes disorder. As per the correlation analysis data for the girls with adolescence pathology, there were revealed direct average correlation connections between the concentration of steroid hormones and structural-functional properties of bony tissue. Low concentration of progesterone in the blood of girls with adolescence pathology is one of the main reasons for bone content deficit, development of osteoporosis, and scoliosis progression.

Keywords: Osteoporosis, gynecology, menstrual disorders, mineralization disorders, bone mineral density, hip fracture, reproductive health, adolescent health.

[1]
Rachner TD, Khosla S, Hofbauer LC. New horizons in osteoporosis. Lancet 2011; 377: 1276.
[http://dx.doi.org/10.1016/S0140-6736(10)62349-5] [PMID: 21450337]
[2]
Povorozniuk VV. Osteopenic syndrome in children and adolescents: risk factors, diagnosis, prevention. VV Povorozniuk, AB Vilensky, NV Grigoriev. (eds.). Method Manual. Kyiv, Ukraine. 2001; 27.
[3]
Allgrove J, Shaw NJ. Calcium and Bone Disorders in Children and Adolescents. Karger International, Karger AG, Basel 2009; 16: 170-90.
[http://dx.doi.org/10.1159/isbn.978-3-8055-9162-1]
[4]
Cooper C, Aihie A. CyrusCooper. Osteoporosis. Baillieres Clin Rheumatol 1995; 9(3): 555-64.
[http://dx.doi.org/10.1016/S0950-3579(05)80258-4] [PMID: 7497538]
[5]
Fromigué O, Haÿ E, Barbara A, et al. Calcium sensing receptor‐dependent and receptor‐independent activation of osteoblast replication and survival by strontium ranelate. J Cell Mol Med 2009; 13(8B): 2189-99.
[http://dx.doi.org/10.1111/j.1582-4934.2008.00673.x]
[6]
Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005; 115(12): 3318-25.
[http://dx.doi.org/10.1172/JCI27071] [PMID: 16322775]
[7]
Riggs BL, Parfitt AM. Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res 2005; 20(2): 177-84.
[http://dx.doi.org/10.1359/JBMR.041114] [PMID: 15647810]
[8]
World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series 843. WHO, Geneva..
[9]
Kanis JA, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A. Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone 2000; 27(5): 585-90.
[http://dx.doi.org/10.1016/S8756-3282(00)00381-1] [PMID: 11062343]
[10]
Hui SL, Slemenda CW, Johnston CC Jr. Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 1988; 81(6): 1804-9.
[http://dx.doi.org/10.1172/JCI113523] [PMID: 3384952]
[11]
De Laet CEDH, van Hout BA, Burger H, Hofman A, Pols HAP. Bone density and risk of hip fracture in men and women: cross sectional analysis. BMJ 1997; 315(7102): 221-5.
[http://dx.doi.org/10.1136/bmj.315.7102.221] [PMID: 9253270]
[12]
Kanis JA, Oden A, Johnell O, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 2007; 18(8): 1033-46.
[http://dx.doi.org/10.1007/s00198-007-0343-y] [PMID: 17323110]


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 1
Year: 2020
Page: [26 - 32]
Pages: 7
DOI: 10.2174/1573404815666190923121305
Price: $65

Article Metrics

PDF: 15
HTML: 3
EPUB: 1
PRC: 1