Background: Inflammation has been shown to accompany Metabolic Syndrome (MetS)
and its features. Cathepsin D is one of a proinflammatory mediator. In the current study, we aimed
to investigate the effect of curcumin supplementation on serum cathepsin D levels in patients with
Methods: The current study was conducted on 18-65 years old individuals with MetS diagnosed
according to the International Diabetes Federation guidelines. A total of 80 participants were
randomly divided into treatment and control groups. The first group (n=40) was given 2 capsules
containing 500 mg of phosphatidylcholine complex of curcumin, and the other group (n=40) was
given two 500 mg placebo capsules for 6 weeks. Before (week 0) and after (week 6) the intervention,
anthropometric indices and blood pressure were measured and blood samples were taken.
Serum cathepsin D was measured using an ELISA kit.
Results: There was no significant difference between treatment and control groups in terms of
weight, body mass index, waist circumference and serum cathepsin D levels before and after the
intervention. In addition, there was no significant difference between pre- and post-trial values of
serum cathepsin D.
Conclusion: The present results do not suggest any effect of curcumin on cathepsin D levels in
patients with MetS.