Objective: The objective of present study was to enhance the potential activities of
Quercetin by improving its solubility and dissolution profiles through solid dispersion approach.
Method: A three level full factorial design (32) was adopted to study the possible combinations of
polyethylene glycol (PEG) 6000 & pluronic F 127 (PF 127). The solid dispersions were prepared
by solvent evaporation method and evaluated for percentage yield, drug content, aqueous solubility
and drug release. For in vivo evaluations SD4 was incorporated into Carbopol base gel and
subjected to anti-inflammatory activity using carrageenan-induced rat paw edema method.
Results: SD4 batch with drug to carrier ratio 1:1 showed release of 82.96 ± 1.76 % in 240 min following
Higuchi’s model. It was 5.54 fold increment in solubility as compared to quercetin. SD4
batch was further evaluated by FTIR, DSC, PXRD and SEM. The crystallinity was significantly
reduced and drug was homogeneously dispersed in the carrier as shown by the results of DSC,
PXRD and SEM. The DPPH scavenging assay showed significance in the IC50 value of SD4 as
compared to pure quercetin and ascorbic acid when subjected to one way ANOVA at 0.05 level of
significance (P<0.0001). In vivo anti-inflammatory study showed 78.17 ± 0.156 % inhibition of
edema by SD4 and 58.64 ± 0.640 % by pure quercetin which is significantly lower (P<0.05).
Conclusion: These findings demonstrate that the solid dispersion of quercetin shows increased
solubility, dissolution profile, drug release and significant potential in enhancing the antiinflammatory
activity of drug.