Background: Behcet's disease is a potentially life threatening autoimmune disease with
recurrent ulcers and unknown pathogenesis. Gender and human leukocyte antigen-B51 seem to
have an effective role in the clinical features of the disease.
Objective: The aim of this study is to evaluate the frequency of HLA-B5, 7, 8, 27 and 51 in behçet's
disease in southwestern Iranian patients who visited the rheumatology clinic and to find the association
between these HLA types and the disease.
Methods: 63 patients with behcet's disease participated in this study and peripheral blood samples
were collected from them. The expression of each HLA antigen was evaluated by standard lymphocytotoxicity
Results: Compared to other studied antigens, the expression of HLA-B5 and HLA-B51 was more
prevalent among our patients. According to the results, 25% and 21% of patients were positive for
HLA-B5 and HLA-B51, respectively.
Conclusions: HLA-B5 and HLA-B51 are dominant positive HLA antigens among behcet's disease
patients in the southwest of Iran; however, we cannot conclude that these antigens are valuable diagnostic
or prognostic biomarkers due to our study limitations. We suggest studying the association
between HLA-B antigens and inflammation severity in patients to determine the possible prognostic
value of HLA-B antigens in Iranian population in the southwest and this region needs more
studies in HLA subject among BD patients because of the frequency of BD to evaluate the value of
HLA typing in BD prognosis.