Title:Bilosomes: Superior Vesicular Carriers
VOLUME: 15 ISSUE: 4
Author(s):Pradnya Palekar-Shanbhag*, Supriya Lande, Riya Chandra and Drushti Rane
Affiliation:Department of Pharmaceutics, Oriental College of Pharmacy, Sanpada, University of Mumbai, Mumbai, Department of Pharmaceutics, Oriental College of Pharmacy, Sanpada, University of Mumbai, Mumbai, Department of Pharmaceutics, Oriental College of Pharmacy, Sanpada, University of Mumbai, Mumbai, Department of Pharmaceutics, Oriental College of Pharmacy, Sanpada, University of Mumbai, Mumbai
Keywords:Bilosomes, vesicular carriers, vaccine delivery, bile salts, liposomes, niosomes.
Abstract:In the current era, many formulations have been designed in the form of vesicular carriers
like liposomes and niosomes which have been proved to be one of the potential candidates for
drug delivery by the oral route but due to the gastrointestinal environment i.e. pH, presence of enzymes,
and bile salts, their use is limited. Because of these difficulties, research is being done to
increase the stability and efficacy of the drug. Thus bilosomes have been developed as a potential
vesicular carrier system for oral vaccine delivery, transdermal and parenteral targeted drug delivery.
The present article covers various aspects related to the novel vesicular system that is based on bile
salts called bilosomes, for targetted drug delivery systems. It includes information related to bilosome
composition, formulation techniques, characterization methods, applications in oral immunization
as vaccine delivery approach and advantages over conventional nanocarriers such as
liposomes and niosomes. It also focuses on the stability and applications of bilosomes along
with scalability and potentiality in biomedical field of oral immunization against various dreadful
diseases.
