Background: Microfluidic channels have been widely applied in biomedicine and microelectronics.
However, the manufacturing methods of microfluidic channel devices, such as photolithography,
three-dimensional printing and Melt-electrospinning direct writing (MEDW), have the problem
of high cost and complex process, which still can't reach a sub-micron scale stably.
Method: To improve the resolution of microfluidic channels, we developed a simple and flexible
method to fabricate polydimethylsiloxane (PDMS) submicrofluidic channels. It depends on the following
steps: (1) Direct Writing Polyethylene oxide (PEO) nanofiber by Near-field Electrospinning
(NFES). (2) Packaging the nanofiber with PDMS. (3) Obtaining the PDMS submicrofluidic channel
by inverted mode of PEO nanofiber.
Results: According to the result of the experiment, nanofiber can be stably prepared under the following
conditions, the electrode-to-collector distance of 3.0 mm, the voltage of 1.7 KV, the collector
moving speed of 80mm/s and the mixed solutions of ethanol and deionized water (1:1). Finally, the
PDMS submicrofluidic channel was manufactured by NFES and PDMS molding technique, and the
diameter of the channel was 0.84±0.08 μm.
Conclusion: The result verified the rationality of that method. In addition, the method can be easily
integrated with high resolution channels for various usages, such as microelectronics, micro electro
mechanical systems, and biomedical.