A convenient and cost-effective method for selective deuteration of rutin using biologically
compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is
benign and inexpensive affording good results in very mild conditions allowing to reduce the required
amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be
conveniently followed by 1H-NMR.
Keywords: Rutin, arginine, deuterium oxide, NMR, TRIS, solvent.
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