Objective: This mini-review aims to discuss research works about heparanase published in
2016, 2017, 2018 and 2019 and provide a direction for therapy methods targeting heparanase.
Patients and Methods: The relevant data were searched by using keywords “heparanase” “function”,
“diseases” and “inhibitors” in “PubMed”, “Web of Science” and “China Knowledge Resource Integrated
databases (CNKI)”, and a hand-search was done to acquire peer-reviewed articles and reports
Results: Except for tumor progression, pathological processes including procoagulant activities,
preeclamptic placentas, inflammation and so on are all verified to be associated with heparanase activity.
Also, these newly-found functions are closely related to certain cellular activities, including epithelial
to Mesenchymal Transition (EMT).
Conclusion: It could be concluded that heparanase would be a potential and valuable therapy target.