Benzocaine: Review on a Drug with Unfold Potential

Author(s): Syeda Khair-ul-Bariyah, Muhammad Arshad*, Muhammad Ali, Muhammad Imran Din, Ahsan Sharif, Ejaz Ahmed

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 1 , 2020

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Graphical Abstract:


Benzocaine is well-known for its role as an anesthetic agent and largely used in oral ulcers, ear pain and dental complications. Along with lidocaine and other local anesthetics, benzocaine has marked it as an anesthetic agent in surgical procedures and as Na+ channels blocker, as well. Analogues of benzocaine have been found to possess biological potentials including antibacterial, antifungal and anti-cancer. Some derivatives were found to have conspicuous action against tuberculosis. The current review focuses to explore the century-long potential of the molecule and its analogs that have appeared in the literature. Furthermore, highlighting the biological potential of benzocaine and its analogues shall open-up new dimensions of future research to design more potent analogues.

Keywords: Benzocaine, anesthetic, antibacterial, antifungal, lidocaine, tuberculosis, cancers, antimutagenic.

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Year: 2020
Published on: 17 January, 2020
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DOI: 10.2174/1389557519666190913145423
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