Title:Voltammetric Method Development for Itopride Assay in a Pharmaceutical Formulation
VOLUME: 16 ISSUE: 3
Author(s):Abdulaziz N. Amro*
Affiliation:Chemistry Department, Faculty of Science, Taibah University, Al Madinah Al Munawwarah
Keywords:Itopride, cyclic voltammetry, linear sweep voltammetry, square wave voltammetry, differential pulse voltammetry,
chromatographic.
Abstract:
Background: Itopride used for the gastrointestinal symptoms caused by reduced gastrointestinal
mobility. For the first time rapid, low cost and green voltammetric method has been applied to
analyze itopride in pharmaceutical formulation.
Methods: Cyclic Voltammetry (CV), Linear Sweep Voltammetry (LSV), Square Wave Voltammetry
(SWV) and Differential Pulse Voltammetry (DPV) methods have been applied in this study.
Results: Na2SO4 (1M) supporting electrolyte exhibited sharper anodic peak current than other used
supporting electrolytes; glassy carbon electrode (GC) working electrode shows better results than platinum
electrode (Pt). SWV results show the lowest limit of detection and quantitation values of 2.3 and
18.1 μg.mL-1, respectively. SWV recovery is 100.56% and 100.46% for 50 μg.mL-1 and 100 μg.mL-1
of commercially available itopride tablets, respectively. Furthermore, SWV inter and intraday results
precessions are better than other used methods with 0.96 and 0.56% RSD, respectively.
Conclusion: The optimum method of applied methods in this study is SWV method. Voltammetry
showed low LOD and LOQ values with high accuracy and precession in addition to comparable repeatability
and reproducibility values.
