Background and Objective: Cyclodextrins have been of great interest as excellent candidates for
fabricating versatile nano-drug delivery systems due to their commercial availability, easy functionalization, low
immunogenicity, biocompatibility and safety. The possibility of reversible inclusion complex formation between
cyclodextrins and various guest molecules in association with versatile exclusive properties of cyclodextrins
offer a route towards the fabrication of highly sophisticated nanostructures with enormous potential for cancer
Methods and Results: The current review discusses important recent advances in the fabrication and development
of cyclodextrin-based nanostructures for cancer therapy. Firstly, the formation of inclusion complexes
between cyclodextrin derivatives and anticancer compounds, as well as their application, are summarized. Secondly,
the cyclodextrins -based nanosystems including cyclodextrin-containing polymers, cyclodextrin-based
supramolecular necklaces, which consist of polyrotaxanes and polypseudorotaxanes and cyclodextrin based
hydrogels accompanied by their applications in cancer treatment are highlighted. In the end, the future perspective
of this field is discussed.
Conclusion: Numerous investigations in this area pave the way for the flourishing of the next generation of
nano-therapeutics towards enhanced cancer therapy.