Background: The most active agents for the treatment of breast cancer are the anthracyclines
whose clinical usefulness is limited by cumulative dose-dependent cardiotoxicity, which results
in congestive heart failure among other limiting factors. With all the attempts to minimize
chemotherapeutic cardiotoxicity, remote ischemic preconditioning (RIPC) has been considered as a
potent endogenous mechanism capable of inhibiting inflammatory responses.
Objective: This study aimed to verify if RIPC may be effective as prophylaxis to prevent anthracycline-
induced cardiotoxicity in oncological patients.
Methods: The preconditioning method was based on four to five-minute cycles of a blood pressure
cuff insufflation around the upper arm (either left or right) from 200 mmHg to 250 mmHg, inducing
ischemic intervals interspersed with 5 minutes of reperfusion.
Results: In this work, echocardiogram results showed a ventricular mass variation that can get worse
during chemotherapeutic treatment; however, in patients who had been undergoing RIPC sessions
over a period of 6 months, it was observed that this change did not occur. The parameters for troponin
T levels were considered; they were higher in patients who were not undergoing RIPC in relation
to those who were. When both cases were compared, it was possible to infer that there was a
clinically significant improvement for those who went through the procedure.
Conclusion: Thus, through the analysis of this study, it is possible to conclude that RIPC is a lowcost,
non-invasive procedure which brings cardiac protection for patients undergoing chemotherapy
with anthracyclines, providing support in the treatment of cancer.