Background: Immune thrombocytopenia (ITP) is an acquired immune mediated disorder
characterized by isolated thrombocytopenia. Pediatric ITP patients can develop autoantibodies such as
anti-thyroglobulin (TG) and anti-thyroperoxidase (TPO), even in the absence of clinical signs of autoimmune
Objective: The purpose of this article is to provide a review about: 1) the prevalence of positivity of
anti-thyroid antibodies (TPO and TG) in pediatric patients with chronic ITP; 2) the role of autoimmune
thyroiditis on the outcome of chronic ITP.
Methods: The authors individually completed a review of the literature for this article. Retrospective
and prospective clinical studies with pediatric cohorts were considered.
Results: From the analysis of data, we found 4 papers which included studies only on pediatric population,
and which corresponded to selected criteria. Pediatric ITP patients have been shown to have a
statistically significant prevalence of anti-thyroid antibodies over healthy controls (11.6-36% versus
1.2-1.3%). No correlation has been found between the platelet count and the prevalence of positive
anti-thyroid antibodies at any time of the follow up.
Conclusion: The results of our bibliographic research demonstrated that: a) pediatric patients with
chronic ITP tend to have a statistically significant prevalence of anti-thyroid antibodies positivity respect
to general pediatric population; b) there are no clear data about the role of autoimmune thyroiditis
as prognostic factor for chronic course of ITP in pediatric age.