A method for gram scale preparation of 2-fluoropropionyl-carfentanil was established, starting
from 4-phenylamino-1-benzyl-4-piperidinecarboxylic acid. 2-Fluoropropionyl-carfentanil carboxylic
acid and 2-chloropropionyl-carfentanil as precursors were synthesized for the radiosynthesis of 11C
and/or 18F labelled 2-fluoropropionyl-carfentanil derivatives via two separate reaction routes. Conformational
analysis of 2-fluoropropionyl-carfentanil was performed using computational methods. Calculated
1H and 13C-NMR shifts are presented.
Keywords: 4-anilidopiperidines, 2-fluoropropionyl-carfentanil, 2-chloropropionyl-carfentanil, positron emission tomography,
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