A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives
from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation
reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials-
catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically
(1H- and 13C-NMR, IR and EI-MS) and by elemental analyses.
Keywords: C-H Activation, isocyanate, Cu-catalyzed, quinazoline-2, 4(1H, 3H)-diones, isocyanides, aniline.
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