Synthesis of Highly Functionalized Quinazoline-2,4(1H,3H)-diones from Isocyanides, Aniline and Isocyanate via Cu-Catalyzed Intermolecular C-H Activation Reactions

Author(s): Manijeh Nematpour, Hossein Fasihi Dastjerdi, Mehdi Jahani, Sayyed Abbas Tabatabai*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 11 , 2020

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Abstract:

A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials- catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically (1H- and 13C-NMR, IR and EI-MS) and by elemental analyses.

Keywords: C-H Activation, isocyanate, Cu-catalyzed, quinazoline-2, 4(1H, 3H)-diones, isocyanides, aniline.

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Article Details

VOLUME: 17
ISSUE: 11
Year: 2020
Page: [832 - 836]
Pages: 5
DOI: 10.2174/1570178616666190905142545
Price: $95

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