Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors

Author(s): Na Ye*, Qingfeng Xu, Wanwan Li, Pingyuan Wang, Jia Zhou*

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 23 , 2019

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Graphical Abstract:


Abstract:

The Ras proteins play an important role in cell growth, differentiation, proliferation and survival by regulating diverse signaling pathways. Oncogenic mutant K-Ras is the most frequently mutated class of Ras superfamily that is highly prevalent in many human cancers. Despite intensive efforts to combat various K-Ras-mutant-driven cancers, no effective K-Ras-specific inhibitors have yet been approved for clinical use to date. Since K-Ras proteins must be associated to the plasma membrane for their function, targeting K-Ras plasma membrane localization represents a logical and potentially tractable therapeutic approach. Here, we summarize the recent advances in the development of K-Ras plasma membrane localization inhibitors including natural product-based inhibitors achieved from high throughput screening, fragment-based drug design, virtual screening, and drug repurposing as well as hit-to-lead optimizations.

Keywords: RAS, K-Ras, K-Ras mutation, Plasma membrane localization inhibitors, Cancer, Drug discovery.

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