Background: Benzothiazoles are reported to have bioorganic and pharmaceutical chemistry
Introduction: A series of substituted N-bromoamido-2-aminobenzothiazoles was synthesized from substituted
anilines via 2-aminobenzothiazoles and it was further evaluated for its antimicrobial activity.
Methods: All the newly synthesized compounds were characterized by FT-IR, NMR and mass
spectra and purity profiles were studied by HPLC analysis. The antimicrobial testing (MIC determination)
was newly performed with agar micro-broth dilution method for these analogs.
Results: Among the synthesized compound 3b showed the highest activity with MIC value of 3.12
μg/mL against Bacillus, E. coli, S. aureus and Klebsiella and 6.25 μg/mL against C. albicans. The
ADME properties as calculated by using Qikprop were found within acceptable range. Derivatives
shows a good-moderate binding affinity towards target Cytochrome P450 14 alpha-sterol demethylase
(CYP51) (PDB ID: 1EA1).
Conclusion: Our in-silico and in-vitro studies on a series of substituted aminobenzothiazoles may
be helpful for further designing of more potent antimicrobials in future.