In silico Insights on IL-6: A Potential Target for Multicentric Castleman Disease

Author(s): Abhishek Aher, Trishang Udhwani, Ravina Khandelwal, Akanksha Limaye, Tajamul Hussain, Anuraj Nayarisseri*, Sanjeev Kumar Singh*

Journal Name: Current Computer-Aided Drug Design

Volume 16 , Issue 5 , 2020

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Abstract:

Background: Multicentric Castleman Disease (MCD) is a confrontational lymphoproliferative disorder described by symptoms such as lymph node proliferation, unwarranted secretion of inflammatory cytokines, hyperactive immune system, and in severe cases, multiple organ dysfunction. Interleukin-6 (IL-6) is a pleiotropic cytokine which is involved in a large range of physiological processes in our body such as pro-inflammation, anti-inflammation, differentiation of T-cells and is reported to be a key pathological factor in MCD. In the case of MCD, it was observed that IL-6 is overproduced from T-cells and macrophages which disturb Hepcidin, a vital regulator of iron trafficking in macrophage. The present study endeavour to expound the inhibitor which binds to IL-6 protein receptor with high affinity.

Methods: MolegroVirtual Docker software was employed to find the best-established drug from the list of selected inhibitors of IL-6. This compound was subjected to virtual screening against PubChem database to get inhibitors with a very similar structure. These inhibitors were docked to obtain a compound binding with high affinity to the target protein. The established compound and the virtual screened compound were subjected to relative analysis of interactivity energy variables and ADMET profile studies.

Results: Among all the selected inhibitors, the virtual screened compound PubChem CID: 101119084 is seen to possess the highest affinity with the target protein. Comparative studies and ADMET analysis further implicate this compound as a better inhibitor of the IL-6 protein.

Conclusion: Hence, this compound recognized in the study possesses high potential as an IL-6 inhibitor which might assist in the treatment of Multicentric Castleman Disease and should be examined for its efficiency by in vivo studies.

Keywords: IL-6 Inhibitors, multicentric castleman disease, virtual screening, molecular docking, ADMET, toxicity study.

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Article Details

VOLUME: 16
ISSUE: 5
Year: 2020
Published on: 09 November, 2020
Page: [641 - 653]
Pages: 13
DOI: 10.2174/1573409915666190902142524
Price: $65

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