Is Pouch Specific to Colon and Not Ileum?

Author(s): Sonal Gupta, Pradeep Tiwari, Nidhi Gupta, Vandana Nunia, Amulya K Saxena, Anita Simlot, Shanker Lal Kothari, Prashanth Suravajhala, Krishna Mohan Medicherla, Praveen Mathur*

Journal Name: Current Pediatric Reviews

Volume 15 , Issue 4 , 2019


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Abstract:

Background: Congenital Pouch Colon (CPC) is an anorectal anomaly with an incidence of 3.5:1 in males and females, respectively. We have earlier reported CPC to be quite prevalent in north Indian tertiary care centers.

Objective: In this article, we deliberate on the possible causes associated with CPC bringing the manifestation of the disease. In addition, we throw insights on the effective role of this congenital anomaly in Colon and provide systems genomic evaluation by comparing our recent analysis to that of Colon and Ileum based on Next-Generation Sequencing (NGS) studies.

Conclusion: In this commentary article, we argue that a host of epigenetic factors could be the reason why the disease is manifested in colon alone. We further hypothesize on the few unmet challenges linking epigenetics to understand the genetic variants.

Keywords: Congenital pouch colon, anorectal malformation, colovesical fistula, colostomy, imperforate anus, systems genomics.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2019
Published on: 30 December, 2019
Page: [259 - 264]
Pages: 6
DOI: 10.2174/1573396315666190829155930

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