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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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General Review Article

Chitosan and Quercetin: Potential Hand in Hand Encountering Tumors in Oral Delivery System

Author(s): Jalil Rashedi, Amir Ghorbanihaghjo*, Mohammad Asgharzadeh and Behzad Baradaran*

Volume 25, Issue 28, 2019

Page: [3074 - 3086] Pages: 13

DOI: 10.2174/1381612825666190829144508

Price: $65

Abstract

Chitosan is a cationic polysaccharide and multi-potential polymer with the ability to interact with other natural and synthetic polyanionic/polymeric compounds, with or without a cross-linking agent. It has been able to composite nano-microparticles with a variety of features. This compound has the ability to carry quercetin, as an anti-tumor subject, through the various epithelial systems and release in the sustained and controlled state to the target site.

This paper reviews published studies on detailed physicochemical properties of chitosan and quercetin in the fight against the tumor. This also focused on how the chitosan polymer interacts with other polymeric and polyanion species in order to improve its efficiency to make a more suitable capsule or matrix for a variety of drugs, especially quercetin, in oral delivery systems.

Keywords: Chitosan, quercetin, drug delivery system, interaction, polymer, crosslinking, cancer therapy.

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