Background: Magnesium deficiency is a global nutritional problem which seems to influence
obesity-associated metabolic disorders because magnesium plays an important role in the prevention
and treatment of many diseases.
Objective: We conducted a systematic review and meta-analysis to evaluate the relationship between
plasma magnesium concentrations and obesity.
Methods: A systematic review and meta-analysis of case-control studies was conducted. Relevant
studies were identified from a literature search using electronic databases.
Results: Ten case-control studies were evaluated in this meta-analysis. Results demonstrated that
obese individuals presented lower plasma magnesium concentration than healthy individuals (standardized
mean difference [SMD] = -0.44, 95% confidence interval = -0.88 to -0.01). In subgroup
analyses, there were differences in plasma magnesium concentration between obese and healthy individuals
according to study location, gender, case age, control age, method for assessment of magnesium
concentration and study quality. Furthermore, meta-regression analyses showed that the
source of heterogeneity of magnesium levels among studies was control age.
Conclusion: Evidence of this systematic review and meta-analysis show hypomagnesemia in obese
individuals of both genders.