Background: Adiponectin and 8-Hydroxy-2′-deoxyguanosine (8-OHdG) are
identified as important biomarkers in the pathogenesis process of type 2 diabetes
mellitus (T2DM). Whether adiponectin and 8-OHdG have a relation to cognitive decline
in the elderly T2DM patients has been poorly understood. The aim of this study was to
evaluate the effects of adiponectin and 8-OHdG in the elderly patients with T2DM and to
determine the role of adiponectin and 8-OHdG in the cognitive impairment of the elderly
patients with T2DM.
Methods: 57 individuals were recruited and analyzed , with 26 cases of T2DM without
cognitive impairment and 31 cases of T2DM with cognitive impairment. All of them
underwent an examination of diabetes scales and blood glucose at different times. A
primary diagnosis of diabetes was in line with the diagnosis criteria set by the American
Diabetes Association (ADA). Statistical significance was defined as a P-value of less
Results: The variables of sex, age, body mass index (BMI), hypertension, diabetes,
metabolic syndrome, lacunar cerebral infarction, smoking and drinking in T2DM patients
without cognitive impairment and with cognitive impairment showed no difference
according to the univariate analysis exploring each variable separately (p>0.05). A
significant difference was observed in the serum levels of adiponectin and 8-OHdG and
the scales of MMSE and MoCA (p<0.05).
there is no
correlation between glucose metabolic value and cognitive outcome of T2DM patients.
Serum levels of adiponectin and 8-OHdG could act as biomarkers of cognitive
impairment degree in the elderly T2DM patients.
Conclusion: Serum levels of adiponectin and 8-OHdG could act as specific and
sensitive biomarkers for the early diagnosis and treatment of cognitive impairment in
elderly T2DM patients. Serum levels of adiponectin and 8-OHdG have a close relation to
the neurological cognitive outcome of
the elderly T2DM patients.