Background: Coagulase negative Staphylococci (CoNS) are important. The common
antibiotics used for the treatment of the infections caused by CoNS are penicillin, oxacillin, ciprofloxacin,
clindamycin, erythromycin, gentamicin, and vancomycin. Linezolid is an oxazolidinone
group of antibiotic with activity against Gram-positive bacteria. It is used for the treatment of serious
infections caused by Gram-positive bacteria resistant to other antibiotics, including streptococci,
vancomycin-resistant enterococci (VRE).
Aims and Objective: This study emphasizes on the judicious use of newer antibiotics to contain
the spread of resistance.
Method: We are discussing five cases of Linezolid resistant Staphylococcus Haemolyticus which
were reported in our laboratory during one year from patients with device related infections and
also review of literature is being presented for an update.
Result: In our study, the isolates were resistant to other groups of antimicrobials but susceptible to
glycopeptides. All the isolates were methicillin-resistant.
Conclusion: Linezolid is approved as an alternative drug to be given for catheter-related bloodstream
infections. In earlier studies, linezolid-resistant staphylococci have been reported increasingly
all over the world. This study is to create awareness amongst clinicians that improper and
excessive use of linezolid will make this antibiotic-resistant and thus will be of no help in future,
so judicious and relevant use of antibiotics needs to be emphasized.