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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Squaramide-Catalyzed Enantioselective Michael Addition of Pyrazol-3- ones to ortho-Quinone Methides

Author(s): Laura Carceller-Ferrer, Gonzalo Blay*, José R. Pedro* and Carlos Vila

Volume 17, Issue 11, 2020

Page: [837 - 844] Pages: 8

DOI: 10.2174/1876402911666190806105543

Price: $65

Abstract

A bifunctional squaramide catalyzed the enantioselective Michael addition of pyrazol-3- ones to ortho-quinone methides, generated in situ from 2-(1-tosylalkyl)phenols is presented. The corresponding chiral pyrazolones are obtained with good to excellent yields (27-98%) and enantiomeric excess (14-99% ee).

Keywords: Asymmetric catalysis, organocatalysis, ortho-quinone methides, pyrazolones, Michael reaction.

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