An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions
such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to
provide information on mosquito saliva allergens that can support the production of highly specific
recombinant saliva allergens. In particular, candidate allergens of mosquitoes that are well suited to the
ecology of mosquitoes that occur mainly in East Asia will be identified and introduced. By doing so,
the diagnosis and treatment of patients with severe sensitivity to mosquito allergy will be improved by
predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production
of recombinant allergens, and understanding the difference between East and West.