Background and Aims: Sedation and analgesia are important elements of endoscopic
examinations; sedation for colonoscopy aims to relieve patient discomfort and anxiety, improve the
outcome of the examination, diminish the patient’s memory of the event and achieve comfortable
and technically successful endoscopic procedure.
Methods: Our prospective study was carried out on 150 patients who were referred for colonoscopy;
they were divided into two groups based on the pre-endoscopic sedation given for them: propofol
fentanyl or propofol ketamine. Detailed histories, thorough physical examinations, and routine
laboratory investigations were performed for all patients, along with monitoring of their vital signs and
oxygen saturation levels (before, during and after colonoscopy), to assess safety, efficacy, recovery
times, complications of the sedative drugs, comfort of the patients and endoscopists.
Results: There was no statistically significant difference between the two groups in terms of age,
sex and Body Mass Indexes (BMI). With respect to their Mean Arterial Blood Pressures (MAPs)
and heart rates, there was high hemodynamic stability in the propofol ketamine group, and both the
groups were efficacious, although the propofol fentanyl group had shorter recovery times than the
propofol ketamine group (3±1.7 minutes and 4±2.8 minutes, respectively). However, nausea, vomiting
and hypoxia were common in the propofol fentanyl group, while hallucinations were common
in the propofol ketamine group. In propofol fentanyl group; there was a significant decrease in the
heart rate more common in females (with age range 39-58 years) during and after colonoscopy
[p value 0.01].
Conclusion: Sedation with propofol ketamine during colonoscopy was found to be safe and
efficacious to achieve hemodynamic stability with fewer complications than propofol fentanyl.