Background: Phytochemical studies on the ethanolic extract of aerial parts of
Alstonia scholaris lead to the isolation of two new triterpenoid of the lanostanetype, lanosta
5ene,24-ethyl-3-O-β-D-glucopyranoside (1), lanosta,5ene,24-ethyl-3-O-β-D-glucopyranosideester
(2) and new ursane type triterpenoidmethylester, 12-ursene-2,3,18,19-tetrol,28
acetate (nighascholarene) (3), together with seven known triterpenes, betuline, triterpene of
the lupane type, alstoprenyol (4), 3β-hydroxy-28-β-acetoxy-5-olea triterpene (5),α-amyrin
acetate (6), α-amyrin (7), lupeol acetate (8), 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene
(9) and ursolic acid (l0).
Methodology: The triterpenoid structures of these colorless compounds were deduced from
the 1H and 13C-NMR data, and in particular from the application of two-dimensional 1H,
13C correlation experiments as well as by comparison with reported literature data.
Results and Conclusion: This study deals with isolation and structural elucidation of natural
new triterpenoidesters and glycosides with anti-inflammatory activity.