Objective: The aim of this study was to investigate the association of Sex Hormone Binding
Globulin (SHBG) with leptin, Triidothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women
with low and normal Resting Energy Expenditure (REE) and to determine the role of these factors in the
regulation of REE in obese women.
Method: A total 49 subjects (25-50 years old) were selected. Anthropometric and body composition
parameters and resting energy expenditure were measured. Fasting circulating leptin, T3, SHBG and
UCP2 levels were measured. Subjects were divided into three groups: Group І (BMI>30 and low resting
energy expenditure, 16 subjects), group II (BMI>30 and normal resting energy expenditure, 17 subjects),
and group ІІІ (control group, 16 non-obese subjects).
Result: It was found that obese subjects who had higher SHBG and leptin levels were at risk for high
levels of UCP2. A significant association was found between T3 and REE. Obese subjects with higher
concentrations of UCP2 and SHBG had decreased resting energy expenditure. A significant association
was observed between SHBG and leptin in group І (r=0.90, p<0.0001) and group ІІ (r=0.83, p<0.0001).
Moreover, a significant association was found between T3 and SHBG in group І (r=-0.69, P=0.003).
Conclusion: Changes of the UCP2, leptin, and thyroid hormone (T3) levels may be related to SHBG
levels. Thus, lower leptin and T3 levels may decrease SHBG in obese women. Therefore, lower SHBG,
leptin, T3 and UCP2 levels may decrease the REE level in obese women.