Background: A series of new six thiazolyl-2-amine-based Schiff base derivatives (4a-4f) were
synthesized by a sequential multistep reaction starting with Salicylaldehyde.
Methods: All the Schiff base derivatives were screened in-vitro for their antibacterial activity against Mycobacterium
tuberculosis (H37RV strain) ATCC No-27294. The synthesized compounds were characterized
by FTIR, 1H-NMR, 13C-NMR and Mass spectrometry.
Results: Among the compounds tested, 4c and 4f derivatives exhibited potent antitubercular activity
against M. tuberculosis at MIC 6.25 μg/mL.
Conclusion: We extended our study to explore the inhibition mechanism by conducting molecular docking
analysis by using Schrodinger’s molecular modeling software. All the newly synthesized compounds were
found to be in-silico AMES test non-toxic and non-carcinogens. The good Qikprop’s Absorption, Distribution,
Metabolism and Excretion (ADMET) would definitely help the researchers in order to make more potent