Fabrication and in-vitro Investigation of Polycaprolactone - (Polyvinyl Alcohol/Collagen) Hybrid Nanofiber as Anti-Inflammatory Guided Tissue Regeneration Membrane

Author(s): Mazdak Limoee, Pouran Moradipour, Mahnaz Godarzi, Elham Arkan, Leila Behbood*

Journal Name: Current Pharmaceutical Biotechnology

Volume 20 , Issue 13 , 2019

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Graphical Abstract:


Background: Periodontal disease is the most common oral condition that affects the tissue surrounding the teeth. The oral cavity is colonized by an impressive array of micro-organisms, many of which can colonize the implants such as Guided Tissue Regeneration (GTR) often utilized in recovering procedures that result in inflammation interfering with the bone regeneration.

Methods: In the current study, a nano-hybrid GTR membrane is developed as a heliacal structure scaffold with localized drug delivery function (Ibuprofen) as an anti-inflammatory agent. Polycaprolactone (PCL) and a blend of Polyvinyl alcohol (PVA)/collagen (Col) (50/50) were electrospun by electrospinning. Ibuprofen (Ibu) was loaded once in the PCL context and once in the hydrophilic portion (PVA/Col).

Results: The in vitro release behavior was investigated in each case. Chemical and physical properties were studied for each item. Morphology investigation indicated a heliacal structure with the total average diameter of 1266 nm consististing of porous pores with the average diameter of 256nm.

Conclusion: The membranes indicated proper mechanical properties and appropriate biodegradation rate as a potential GTR membrane. The controlled and sustained release of Ibu was obtained from both PCL and PVA/COL loaded membranes. Kinetic model study indicated the following zero-order and Higuchi models for the optimum case of PCL loaded and PVA/Col Ibu loaded scaffolds respectively.

Keywords: Dental materials, guided tissue regeneration, nanofiber, ibuprofen, electrospinning, controlled release, scaffold, anti-inflammatory.

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Year: 2019
Page: [1122 - 1133]
Pages: 12
DOI: 10.2174/1389201020666190722161004
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