Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health
problem in the modern world. Many drugs have been tested to control hyperglycemia which is believed to be the
main factor behind many of the diabetes-related late-term complications. Wogonin is a famous herbal medicine
which has been shown to be effective in controlling diabetes and its complications. In our previous work, we
showed that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we
mainly explained wogonin anti-hyperglycemic property through AKT/GLUT4 pathway. Here we briefly discussed
that wogonin increases Glut4 trafficking to plasma membrane which allows increased entry of glucose and
thus alleviates hyperglycemia.
Conclusion: Wogonin can be used as an anti-diabetic and anti-hyperglycemic drug and works via AKT/GLUT4
Keywords: Insulin, Glut4, AKT, hyperglycemia, diabetes mellitus, anti-diabetic.
Fu Y, Luo J, Jia Z, Zhen W, Zhou K, Gilbert E, et al. Baicalein protects against type 2 diabetes via promoting islet β-cell function in obese diabetic mice. Int J Endocrinol 2014; 2014846742
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