Research on Gastric Cancer’s Drug-resistant Gene Regulatory Network Model

Author(s): Zhi Li, Tianyue Zhang, Haojie Lei, Liyan Wei, Yuanning Liu, Yadi Shi, Shuyi Li, Bowen Shen, Hao Guo, Zhangqian Chen, Xiaorong Yi, Hao Zhang*.

Journal Name: Current Bioinformatics

Volume 15 , Issue 3 , 2020

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Abstract:

Objective: Based on bioinformatics, differentially expressed gene data of drug-resistance in gastric cancer were analyzed, screened and mined through modeling and network modeling to find valuable data associated with multi-drug resistance of gastric cancer.

Methods: First, data sets were preprocessed from three aspects: data processing, data annotation and classification, and functional clustering. Secondly, based on the preprocessed data, each classified primary gene regulatory network was constructed by mining interactions among the genes. This paper computed the values of each node in each classified primary gene regulatory network and ranked these nodes according to their scores. On the basis of this, the appropriate core node was selected and the corresponding core network was developed.

Results and Conclusion: Finally, core network modules were analyzed, which were mined. After the correlation analysis, the result showed that the constructed network module had 20 core genes. This module contained valuable data associated with multi-drug resistance in gastric cancer.

Keywords: Gastric cancer, multi-drug resistance, differentially expressed genes, gene regulatory networks, data annotation, clustering.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2020
Page: [225 - 234]
Pages: 10
DOI: 10.2174/1574893614666190722102557
Price: $65

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