Di[(R)-2-ethylhexyl] Phthalate, a Bioactive Metabolite First Isolated from Three Different Bacillus Species, and its Synthesis

Author(s): Miriam Castro, Jacqueline Jiménez, Aurelio Ortiz*, Estibaliz Sansinenea*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 2 , 2020


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Abstract:

Di(2-ethylhexyl) phthalate (DEHP) is the most common phthalate ester, which has been used as a plasticizer for the production of numerous polymers, particularly polyvinyl chloride (PVC). Many other groups have synthesized meso-DEHP indicating interest in this molecule, but we are the first to synthesize enantiomerically pure di[(R)-2-ethylhexyl] phthalate. We report herein, for the first time, the isolation - from the cultures of Bacillus thuringiensis, B. subtilis, and B. velezensis strains - of di[(R)-2-ethylhexyl] phthalate, enantiomerically pure and in good yields: its biological activity against bacteria and fungi was probed and for the first time its synthesis was done.

Keywords: Di(2-ethylhexyl) phthalate, plasticizer, secondary metabolites, synthesis of enantiomers.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2020
Published on: 07 January, 2020
Page: [90 - 95]
Pages: 6
DOI: 10.2174/1570178616666190718125617
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