Scabies: A Neglected Global Disease

Author(s): Alexander K.C. Leung*, Joseph M. Lam, Kin F. Leong

Journal Name: Current Pediatric Reviews

Volume 16 , Issue 1 , 2020

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Graphical Abstract:


Abstract:

Background: Scabies is a skin disease caused by an obligate human parasite mite Sarcoptes scabiei var. hominis. Children under the age of two and elderly individuals are at the greatest risk. Knowledge of this condition is important for an early diagnosis to be made and treatment to be initiated.

Objective: The review aimed to familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of scabies.

Methods: A search was conducted using Pubmed with the built-in "Clinical Queries" tool. The search term "Scabies" was used. The categories of "epidemiology", "diagnosis", "therapy", "prevention" and "prognosis" had a limited scope for primary clinical studies. Meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews were included. Only papers published in the English language were included. A descriptive, narrative synthesis was provided of the retrieved articles.

Results: Worldwide, scabies affects 200 to 300 million individuals annually. The average prevalence is estimated to be 5 to 10% in children of developing countries. Transmission usually occurs after close prolonged skin-to-skin contact. Classic scabies is characterized by an erythematous papular eruption, serpiginous burrows, and intense pruritus. Sites of predilection include the webs of the fingers, volar wrists, lateral aspects of fingers, extensor surfaces of elbows and knees, waist, navel, abdomen, buttocks, groins, and, genitals. A clinical diagnosis of classic scabies can be made on the basis of the history and clinical findings. Other clinical variants include crusted scabies, nodular scabies, and bullous scabies. Finding the mite, ova, or fecal pellets on microscopic examination of scrapings taken from skin lesions confirms the diagnosis of scabies infestation. For eradication of scabies mites, the drugs of choice are topical permethrin and oral ivermectin.

Conclusion: Scabies is a highly contagious parasitic cutaneous disease that is stigmatising and debilitating. Increased awareness, accurate diagnosis, and prompt treatment are essential for the effective control of scabies and for the prevention of the spread of the disease.

Keywords: Intractable pruritus, ivermectin, permethrin, Sarcoptes scabiei var. hominis, serpiginous burrows.

[1]
Day I, Nelson C, Elliot J. Dermacase. Can you identify this condition? Scabies. Can Fam Physician 2013; 59(8): 853-4.
[PMID: 23946030]
[2]
Goldstein BG, Goldstein AO. Scabies: epidemiology, clinical features, and diagnosis UpToDate Available from: https: //www.uptodate.com/contents/scabies-epidemiology-clinical-features-and-diagnosis
[3]
Chang AY, Fuller LC. Scabies - an ancient disease with unanswered questions in modern times. JAMA Dermatol 2018; 154(9): 999-1000.
[http://dx.doi.org/10.1001/jamadermatol.2018.1891] [PMID: 30027219]
[4]
Gladstone HB, Darmstadt GL. Crusted scabies in an immunocompetent child: treatment with ivermectin. Pediatr Dermatol 2000; 17(2): 144-8.
[http://dx.doi.org/10.1046/j.1525-1470.2000.01736.x] [PMID: 10792808]
[5]
Engelman D, Fuller LC, Steer AC. Consensus criteria for the diagnosis of scabies: A Delphi study of international experts. PLoS Negl Trop Dis 2018; 12(5)e0006549
[http://dx.doi.org/10.1371/journal.pntd.0006549] [PMID: 29795566]
[6]
Hon KL, Leung AK. Scabies in toddler twins. Consultant for Pediatricians 2012; 11: 237-9.
[7]
Executive Committee of Guideline for the Diagnosis and Treatment of Scabies. Guideline for the diagnosis and treatment of scabies in Japan (third edition): Executive Committee of Guideline for the Diagnosis and Treatment of Scabies. J Dermatol 2017; 44(9): 991- 1014.
[8]
Hicks MI, Elston DM. Scabies. Dermatol Ther 2009; 22(4): 279-92.
[http://dx.doi.org/10.1111/j.1529-8019.2009.01243.x] [PMID: 19580575]
[9]
Shimose L, Munoz-Price LS. Diagnosis, prevention, and treatment of scabies. Curr Infect Dis Rep 2013; 15(5): 426-31.
[http://dx.doi.org/10.1007/s11908-013-0354-0] [PMID: 23904181]
[10]
Sunderkötter C, Feldmeier H, Fölster-Holst R, et al. S1 guidelines on the diagnosis and treatment of scabies - short version. J Dtsch Dermatol Ges 2016; 14(11): 1155-67.
[http://dx.doi.org/10.1111/ddg.13130] [PMID: 27879074]
[11]
Ebrahim KC, Alves JB, Tomé LA, et al. Norwegian scabies - rare case of atypical manifestation. An Bras Dermatol 2016; 91(6): 826-8.
[http://dx.doi.org/10.1590/abd1806-4841.20164811] [PMID: 28099611]
[12]
Salavastru CM, Chosidow O, Boffa MJ, Janier M, Tiplica GS. European guideline for the management of scabies. J Eur Acad Dermatol Venereol 2017; 31(8): 1248-53.
[http://dx.doi.org/10.1111/jdv.14351] [PMID: 28639722]
[13]
Thomas J, Christenson JK, Walker E, Baby KE, Peterson GM. Scabies-An ancient itch that is still rampant today. J Clin Pharm Ther 2017; 42(6): 793-9.
[http://dx.doi.org/10.1111/jcpt.12631] [PMID: 28948630]
[14]
Banerji A Scabies. Paediatr Child Health 2015; 20(7): 395-402.
[http://dx.doi.org/10.1093/pch/22.7.395] [PMID: 26527041]
[15]
Arlian LG, Runyan RA, Achar S, Estes SA. Survival and infectivity of Sarcoptes scabiei var. canis and var. hominis. J Am Acad Dermatol 1984; 11(2 Pt 1): 210-5.
[http://dx.doi.org/10.1016/S0190-9622(84)70151-4] [PMID: 6434601]
[16]
Chandler DJ, Fuller LC. A Review of Scabies: An infestation more than skin deep. Dermatology (Basel) 2019; 235(2): 79-90.
[http://dx.doi.org/10.1159/000495290] [PMID: 30544123]
[17]
Micali G, Lacarrubba F, Verzì AE, Chosidow O, Schwartz RA. Scabies: advances in noninvasive diagnosis. PLoS Negl Trop Dis 2016; 10(6)e0004691
[http://dx.doi.org/10.1371/journal.pntd.0004691] [PMID: 27311065]
[18]
Liu JM, Wang HW, Chang FW, et al. The effects of climate factors on scabies. A 14-year population-based study in Taiwan. Parasite 2016; 23: 54.
[http://dx.doi.org/10.1051/parasite/2016065] [PMID: 27905271]
[19]
Stamm LV, Strowd LC. Ignoring the “Itch”: the global health problem of scabies. Am J Trop Med Hyg 2017; 97(6): 1647-9.
[http://dx.doi.org/10.4269/ajtmh.17-0242] [PMID: 29016295]
[20]
Abdel-Raheem TA, Méabed EM, Nasef GA, Abdel Wahed WY, Rohaim RM. Efficacy, acceptability and cost effectiveness of four therapeutic agents for treatment of scabies. J Dermatolog Treat 2016; 27(5): 473-9.
[http://dx.doi.org/10.3109/09546634.2016.1151855] [PMID: 27027929]
[21]
Anderson KL, Strowd LC. Epidemiology, diagnosis, and treatment of scabies in a dermatology office. J Am Board Fam Med 2017; 30(1): 78-84.
[http://dx.doi.org/10.3122/jabfm.2017.01.160190] [PMID: 28062820]
[22]
Maan MA, Maan MS, Sohail AM, Arif M. Bullous scabies: a case report and review of the literature. BMC Res Notes 2015; 8: 254.
[http://dx.doi.org/10.1186/s13104-015-1146-4] [PMID: 26092057]
[23]
Thompson MJ, Engelman D, Gholam K, Fuller LC, Steer AC. Systematic review of the diagnosis of scabies in therapeutic trials. Clin Exp Dermatol 2017; 42(5): 481-7.
[http://dx.doi.org/10.1111/ced.13152] [PMID: 28556185]
[24]
Jannic A, Bernigaud C, Brenaut E, Chosidow O. Scabies Itch. Dermatol Clin 2018; 36(3): 301-8.
[http://dx.doi.org/10.1016/j.det.2018.02.009] [PMID: 29929601]
[25]
Romani L, Steer AC, Whitfeld MJ, Kaldor JM. Prevalence of scabies and impetigo worldwide: a systematic review. Lancet Infect Dis 2015; 15(8): 960-7.
[http://dx.doi.org/10.1016/S1473-3099(15)00132-2] [PMID: 26088526]
[26]
Luo DQ, Huang MX, Liu JH, Tang W, Zhao YK, Sarkar R. Bullous Scabies. Am J Trop Med Hyg 2016; 95(3): 689-93.
[http://dx.doi.org/10.4269/ajtmh.16-0273] [PMID: 27402514]
[27]
Hill TA, Cohen B. Scabies in babies. Pediatr Dermatol 2017; 34(6): 690-4.
[http://dx.doi.org/10.1111/pde.13255] [PMID: 28833468]
[28]
Gopinath H, Aishwarya M, Karthikeyan K. Tackling scabies: novel agents for a neglected disease. Int J Dermatol 2018; 57(11): 1293-8.
[http://dx.doi.org/10.1111/ijd.13999] [PMID: 29663338]
[29]
Bollea Garlatti LA, Torre AC, Bollea Garlatti ML, Galimberti RL, Argenziano G. Dermoscopy aids the diagnosis of crusted scabies in an erythrodermic patient. J Am Acad Dermatol 2015; 73(3): e93-5.
[http://dx.doi.org/10.1016/j.jaad.2015.04.061] [PMID: 26282822]
[30]
Leung AK, Barankin B, Hon KL. What is this extremely pruritic rash with nighttime intensity? Consultant for Pediatricians 2016; 15: 613-6.
[31]
Kim D, Teng J. Scabies infection in a neonate. J Pediatr 2014; 165(6): 1266-1266e1..
[32]
Sechi A, Chessa MA, Patrizi A, Savoia F, Neri I. Periungual scabies in infants: a tough reservoir of mites presenting with lamellar desquamation. Arch Dis Child 2019.
[http://dx.doi.org/10.1136/archdischild-2019-316890]
[33]
Tempark T, Lekwuttikarn R, Chatproedprai S, Wananukul S. Nail scabies: an unusual presentation often overlooked and mistreated. J Trop Pediatr 2017; 63(2): 155-9.
[PMID: 27613759]
[34]
Zou Y, Hu W, Zheng J, Pan M. Nail infestation: an atypical presentation of typical scabies. Lancet 2018; 391(10136): 2272.
[http://dx.doi.org/10.1016/S0140-6736(18)31079-1] [PMID: 29893225]
[35]
Cestari TF, Martignago BF. Scabies, pediculosis, bedbugs, and stinkbugs: uncommon presentations. Clin Dermatol 2005; 23(6): 545-54.
[http://dx.doi.org/10.1016/j.clindermatol.2005.01.013] [PMID: 16325062]
[36]
Chosidow O, Hay RJ. Control of scabies and secondary impetigo: optimising treatment effectiveness in endemic settings. Lancet Infect Dis 2019.
[http://dx.doi.org/10.1016/S1473-3099(19)30068-4]
[37]
Razon FM, Weidman-Evans E. Insight into scabies. JAAPA 2017; 30(2): 1-3.
[http://dx.doi.org/10.1097/01.JAA.0000511790.29560.a2] [PMID: 28098680]
[38]
Rezaee E, Goldust M, Alipour H. Treatment of scabies: comparison of lindane 1% vs. permethrin 5%. Skinmed 2015; 13(4): 283-6.
[PMID: 26861425]
[39]
Bu X, Fan J, Hu X, Bi X, Peng B, Zhang D. Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. An Bras Dermatol 2017; 92(4): 556-8.
[http://dx.doi.org/10.1590/abd1806-4841.20174946] [PMID: 28954112]
[40]
Kutlu NS, Turan E, Erdemir A, Gürel MS, Bozkurt E. Eleven years of itching: a case report of crusted scabies. Cutis 2014; 94(2): 86-88, 95.
[PMID: 25184648]
[41]
Ferreira AA, Esteves A, Mahia Y, Rosmaninho A, Silva A. An itchy problem: a clinical case of crusted scabies. Eur J Case Rep Intern Med 2017; 4(5)000591
[http://dx.doi.org/10.12890/2017_000591] [PMID: 30755943]
[42]
Gupta M, Khalequzzaman M, Jodele S, Mortensen J, Mueller MA, Gupta A. Crusted scabies in a 15-year-old boy with congenital neutropenia and myelodysplastic syndrome. J Clin Oncol 2014; 32(12): e49-51.
[http://dx.doi.org/10.1200/JCO.2012.46.6227] [PMID: 24470010]
[43]
Seidelman J, Garza RM, Smith CM, Fowler VG Jr. More than a mite contagious: crusted scabies. Am J Med 2017; 130(9): 1042-4.
[http://dx.doi.org/10.1016/j.amjmed.2017.05.007] [PMID: 28601538]
[44]
Bimbi C, Brzezinski P, Sokolowska-Wojdylo M. Crusted (Norwegian) scabies as a strong marker of adult T-cell leukemia/lymphoma in HTLV-1 infection. Clin Case Rep 2019; 7(3): 474-6.
[http://dx.doi.org/10.1002/ccr3.1983] [PMID: 30899475]
[45]
Lee K, Heresi G, Al Hammoud R. Norwegian scabies in a patient with down syndrome. J Pediatr 2019.
[http://dx.doi.org/10.1002/ccr3.1983]
[46]
Lima FCDR, Cerqueira AMM, Guimarães MBS, Padilha CBS, Craide FH, Bombardelli M. Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant. An Bras Dermatol 2017; 92(3): 383-5.
[http://dx.doi.org/10.1590/abd1806-4841.20174433] [PMID: 29186253]
[47]
Pedra E Cal AP, Ferreira CP, da Costa Nery JA. Crusted scabies in a patient with lepromatous leprosy. Braz J Infect Dis 2016; 20(4): 399-400.
[http://dx.doi.org/10.1016/j.bjid.2016.04.001] [PMID: 27183357]
[48]
Torrelo A, Zambrano A. Crusted scabies in a girl with epidermolysis bullosa simplex. Br J Dermatol 2000; 142(1): 197-8.
[http://dx.doi.org/10.1046/j.1365-2133.2000.03281.x] [PMID: 10819560]
[49]
Wang MK, Chin-Yee B, Lo CK, et al. Crusted scabies in a renal transplant recipient treated with daily ivermectin: A case report and literature review. Transpl Infect Dis 2019; 21(3)e13077
[http://dx.doi.org/10.1111/tid.13077] [PMID: 30873722]
[50]
Baysal V, Yildirim M, Türkman C, Aridogan B, Aydin G. Crusted scabies in a healthy infant. J Eur Acad Dermatol Venereol 2004; 18(2): 188-90.
[http://dx.doi.org/10.1111/j.1468-3083.2004.00846.x] [PMID: 15009301]
[51]
Ramachandra Reddy D, Ramachandra Reddy P. Nodular scabies: a classical case report in an adolescent boy. J Parasit Dis 2015; 39(3): 581-3.
[http://dx.doi.org/10.1007/s12639-013-0365-7] [PMID: 26345076]
[52]
Yanes DA, Faith EF. Nodular scabies: a persistent nodular eruption. Dermatol Online J 2018; 24(8): 18.
[PMID: 30677860]
[53]
Tesner B, Williams NO, Brodell RT. The pathophysiologic basis of scabietic nodules. J Am Acad Dermatol 2007; 57(2)(Suppl.): S56-7.
[http://dx.doi.org/10.1016/j.jaad.2007.04.006] [PMID: 17637380]
[54]
Su WJ, Fang S, Chen AJ, Shan K. A case of crusted scabies combined with bullous scabies. Exp Ther Med 2015; 10(4): 1533-5.
[http://dx.doi.org/10.3892/etm.2015.2668] [PMID: 26622520]
[55]
Salame N, Holland V. Non-pruritic bullous scabies in an immunosuppressed pediatric patient. Pediatr Dermatol 2019; 36(4): 552-3.
[http://dx.doi.org/10.1111/pde.13797] [PMID: 30989695]
[56]
Guergué Díaz de Cerio O, González Hermosa MD, Ballestero Díez M. Bullous scabies in a 5-year-old child. J Pediatr 2016; 179: 270-270.e1.
[http://dx.doi.org/10.1016/j.jpeds.2016.08.078] [PMID: 27671115]
[57]
Luo DQ, Huang MX, Liu JH, Tang W, Zhao YK, Sarkar R. Bullous Scabies. Am J Trop Med Hyg 2016; 95(3): 689-93.
[http://dx.doi.org/10.4269/ajtmh.16-0273] [PMID: 27402514]
[58]
Luo ZY, Zeng M, Gao Q, et al. Case Report: Bullous scabies in two children below 10 years. Am J Trop Med Hyg 2017; 97(6): 1746-8.
[http://dx.doi.org/10.4269/ajtmh.17-0344] [PMID: 29016306]
[59]
Maan MA, Maan MS, Sohail AM, Arif M. Bullous scabies: a case report and review of the literature. BMC Res Notes 2015; 8: 254.
[http://dx.doi.org/10.1186/s13104-015-1146-4] [PMID: 26092057]
[60]
Thean LJ, Engelman D, Kaldor J, Steer AC. Scabies: new opportunities for management and population control. Pediatr Infect Dis J 2019; 38(2): 211-3.
[http://dx.doi.org/10.1097/INF.0000000000002211] [PMID: 30299425]
[61]
Ahmad HM, Abdel-Azim ES, Abdel-Aziz RT. Clinical efficacy and safety of topical versus oral ivermectin in treatment of uncomplicated scabies. Dermatol Ther (Heidelb) 2016; 29(1): 58-63.
[http://dx.doi.org/10.1111/dth.12310] [PMID: 26555785]
[62]
Thomas J, Peterson GM, Walton SF, Carson CF, Naunton M, Baby KE. Scabies: an ancient global disease with a need for new therapies. BMC Infect Dis 2015; 15: 250.
[http://dx.doi.org/10.1186/s12879-015-0983-z] [PMID: 26123073]
[63]
Micheletti RG, Dominguez AR, Wanat KA. Bedside diagnostics in dermatology: Parasitic and noninfectious diseases. J Am Acad Dermatol 2017; 77(2): 221-30.
[http://dx.doi.org/10.1016/j.jaad.2016.06.035] [PMID: 28711083]
[64]
Abdel-Latif AA, Elshahed AR, Salama OA, Elsaie ML. Comparing the diagnostic properties of skin scraping, adhesive tape, and dermoscopy in diagnosing scabies. Acta Dermatovenerol Alp Panonica Adriat 2018; 27(2): 75-8.
[http://dx.doi.org/10.15570/actaapa.2018.17] [PMID: 29945263]
[65]
Werbel T, Hinds BR, Cohen PR. Scabies presenting as cutaneous nodules or malar erythema: reports of patients with scabies surrepticius masquerading as prurigo nodularis or systemic lupus erythematosus. Dermatol Online J 2018; 24(9): 8.
[PMID: 30677831]
[66]
Neri I, Chessa MA, Virdi A, Patrizi A. Nodular scabies in infants: dermoscopic examination may avoid a diagnostic pitfall. J Eur Acad Dermatol Venereol 2017; 31(12): e530-1.
[http://dx.doi.org/10.1111/jdv.14401] [PMID: 28609546]
[67]
Cinotti E, Labeille B, Cambazard F, et al. Videodermoscopy compared to reflectance confocal microscopy for the diagnosis of scabies. J Eur Acad Dermatol Venereol 2016; 30(9): 1573-7.
[http://dx.doi.org/10.1111/jdv.13676] [PMID: 27168425]
[68]
Hahm JE, Kim CW, Kim SS. The efficacy of a nested polymerase chain reaction in detecting the cytochrome c oxidase subunit 1 gene of Sarcoptes scabiei var. hominis for diagnosing scabies. Br J Dermatol 2018; 179(4): 889-95.
[http://dx.doi.org/10.1111/bjd.16657] [PMID: 29624634]
[69]
Gualdi G, Bigi L, Galdo G, Pellacani G. Neonatal Norwegian scabies: three cooperating causes. J Dermatol Case Rep 2009; 3(2): 34-7.
[http://dx.doi.org/10.3315/jdcr.2009.1029] [PMID: 21886727]
[70]
Hon KL, Leung AK, Barankin B. Barrier repair therapy in atopic dermatitis: an overview. Am J Clin Dermatol 2013; 14(5): 389-99.
[http://dx.doi.org/10.1007/s40257-013-0033-9] [PMID: 23757122]
[71]
Hon KL, Leung AKC, Leung TNH, Lee VWY. Investigational drugs for atopic dermatitis. Expert Opin Investig Drugs 2018; 27(8): 637-47.
[http://dx.doi.org/10.1080/13543784.2018.1494723] [PMID: 30058384]
[72]
Rose W, Rajendran G, Peter J. Crusted scabies. Indian Pediatr 2014; 51(8): 680.
[PMID: 25129017]
[73]
Yang YS, Byun YS, Kim JH, Kim HO, Park CW. Infantile scabies masquerading as Langerhans cell histiocytosis. Ann Dermatol 2015; 27(3): 349-51.
[http://dx.doi.org/10.5021/ad.2015.27.3.349] [PMID: 26082604]
[74]
Dastgheib L, Boroujeni NH, Aslani FS. Crusted scabies masquerading as psoriasis plaques in a patient suffering from burn scars. Dermatol Online J 2018; 24(6)
[75]
Matsuura H, Senoo A, Saito M, Fujimoto Y. Norwegian scabies. Cleve Clin J Med 2019; 86(3): 163-4.
[http://dx.doi.org/10.3949/ccjm.86a.18081] [PMID: 30849040]
[76]
Slape DRL, McMeniman E, Currie BJ, Menz J. Clinical diagnosis of crusted scabies: Reverse focal pattern of plantar keratoderma. Australas J Dermatol 2018; 59(3): 233-5.
[http://dx.doi.org/10.1111/ajd.12773] [PMID: 29243244]
[77]
Leung AKC, Lam JM, Leong KF. Childhood solitary cutaneous mastocytoma: Clinical manifestations, diagnosis, evaluation, and management. Curr Pediatr Rev 2019; 15(1): 42-6.
[http://dx.doi.org/10.2174/1573396315666181120163952] [PMID: 30465511]
[78]
Cohen PR. Scabies masquerading as bullous pemphigoid: scabies surrepticius. Clin Cosmet Investig Dermatol 2017; 10: 317-24.
[http://dx.doi.org/10.2147/CCID.S145494] [PMID: 28883737]
[79]
Leung AK, Eneli I, Davies HD. Necrotizing fasciitis in children. Pediatr Ann 2008; 37(10): 704-10.
[http://dx.doi.org/10.3928/00904481-20081001-03] [PMID: 18972853]
[80]
Leung TN, Hon KL, Leung AK, Group A. Group A Streptococcus disease in Hong Kong children: an overview. Hong Kong Med J 2018; 24(6): 593-601.
[http://dx.doi.org/10.12809/hkmj187275] [PMID: 30416105]
[81]
Romani L, Whitfeld MJ, Koroivueta J, et al. Mass drug administration for scabies control in a population with endemic disease. N Engl J Med 2015; 373(24): 2305-13.
[http://dx.doi.org/10.1056/NEJMoa1500987] [PMID: 26650152]
[82]
Robson WL, Leung AK. Post-streptococcal glomerulonephritis: Recent increase of incidence in southern Alberta. Can Fam Physician 1992; 38: 2883-7.
[PMID: 20469533]
[83]
Robson WL, Leung AK. Post-streptococcal glomerulonephritis. Clin Nephrol 1995; 43(2): 139.
[PMID: 7794396]
[84]
Sandoval L, Cuestas D, Velandia A, et al. Scabies herpeticum, an emerging clinical form of crusted scabies in AIDS patient: case report and literature review. Int J Dermatol 2019; 58(10): 1205-9.
[http://dx.doi.org/10.1111/ijd.14256] [PMID: 30320440]
[85]
Shaw K, Smith S, Driscoll M. Scabies herpeticum: crusted scabies with herpes simplex superinfection. G Ital Dermatol Venereol 2017; 152(2): 192-3.
[PMID: 28166621]
[86]
Liu JM, Lin CY, Chang FW, Liu YP, Liang CP, Hsu RJ. Increased risk of psoriasis following scabies infection: A nationwide population-based matched-cohort study. J Dermatol 2018; 45(3): 302-8.
[http://dx.doi.org/10.1111/1346-8138.14221] [PMID: 29356052]
[87]
Engelman D, Steer AC. Control strategies for scabies. Trop Med Infect Dis 2018; 3(3): 98.
[http://dx.doi.org/10.3390/tropicalmed3030098] [PMID: 30274494]
[88]
Witkowski JA, Parish LC. Scabies: a cause of generalized urticaria. Cutis 1984; 33(3): 277-9.
[PMID: 6723363]
[89]
Lin CY, Chang FW, Yang JJ, et al. Increased risk of bipolar disorder in patients with scabies: A nationwide population-based matched-cohort study. Psychiatry Res 2017; 257: 14-20.
[http://dx.doi.org/10.1016/j.psychres.2017.07.013] [PMID: 28709117]
[90]
Liu JM, Hsu RJ, Chang FW, et al. Increase the risk of intellectual disability in children with scabies: A nationwide population-based cohort study. Medicine (Baltimore) 2017; 96(23)e7108
[http://dx.doi.org/10.1097/MD.0000000000007108] [PMID: 28591057]
[91]
Liu JM, Hsu RJ, Chang FW, et al. Increased risk of pernicious anemia following scabies: a nationwide population-based matched-cohort study. Ther Clin Risk Manag 2017; 13: 1205-11.
[http://dx.doi.org/10.2147/TCRM.S137662] [PMID: 29066901]
[92]
Jin-gang A, Sheng-xiang X, Sheng-bin X, et al. Quality of life of patients with scabies. J Eur Acad Dermatol Venereol 2010; 24(10): 1187-91.
[http://dx.doi.org/10.1111/j.1468-3083.2010.03618.x] [PMID: 20236379]
[93]
Chosidow O, Fuller LC. Scratching the itch: is scabies a truly neglected disease? Lancet Infect Dis 2017; 17(12): 1220-1.
[http://dx.doi.org/10.1016/S1473-3099(17)30469-3] [PMID: 28941562]
[94]
Karimkhani C, Colombara DV, Drucker AM, et al. The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015. Lancet Infect Dis 2017; 17(12): 1247-54.
[http://dx.doi.org/10.1016/S1473-3099(17)30483-8] [PMID: 28941561]
[95]
Williams C, Fuller LC. Why does scabies treatment fail? Br J Dermatol 2019; 180(4): 710-1.
[http://dx.doi.org/10.1111/bjd.17612] [PMID: 30933338]
[96]
Goldstein BG, Goldstein AO. Scabies: management.UpToDate.
[97]
Modi K, Patel D, Shwayder T. Scalp-to-toes application of permethrin for patients with scabies. Dermatol Online J 2018; 24(5): 19.
[PMID: 30142746]
[98]
Goldust M, Rezaee E, Raghifar R, Naghavi-Behzad M. Comparison of permethrin 2.5 % cream vs. Tenutex emulsion for the treatment of scabies. Ann Parasitol 2013; 59(1): 31-5.
[PMID: 23829056]
[99]
May PJ, Tong SYC, Steer AC, et al. Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review. Trop Med Int Health 2019; 24(3): 280-93.
[http://dx.doi.org/10.1111/tmi.13198] [PMID: 30582783]
[100]
Pourhasan A, Goldust M, Rezaee E. Treatment of scabies, permethrin 5% cream vs. crotamiton 10% cream. Ann Parasitol 2013; 59(3): 143-7.
[PMID: 24881286]
[101]
Zargari O, Golchai J, Sobhani A, et al. Comparison of the efficacy of topical 1% lindane vs 5% permethrin in scabies: a randomized, double-blind study. Indian J Dermatol Venereol Leprol 2006; 72(1): 33-6.
[http://dx.doi.org/10.4103/0378-6323.19715] [PMID: 16481707]
[102]
Dhana A, Yen H, Okhovat JP, Cho E, Keum N, Khumalo NP. Ivermectin versus permethrin in the treatment of scabies: A systematic review and meta-analysis of randomized controlled trials. J Am Acad Dermatol 2018; 78(1): 194-8.
[http://dx.doi.org/10.1016/j.jaad.2017.09.006] [PMID: 29241784]
[103]
Engelman D, Steer AC. Diagnosis, treatment, and control of scabies: can we do better? Lancet Infect Dis 2018; 18(8): 822-3.
[http://dx.doi.org/10.1016/S1473-3099(18)30372-4] [PMID: 30068496]
[104]
Rosumeck S, Nast A, Dressler C. Ivermectin and permethrin for treating scabies. Cochrane Database Syst Rev 2018; 2018(4) CD012994
[PMID: 29608022]
[105]
Johnstone P, Strong M. Scabies. BMJ Clin Evid 2014; 2014: 1707.
[106]
Johnstone P, Stong M. Scabies. Am Fam Physician 2015; 92(10): 919-20.
[PMID: 26554285]
[107]
Mounsey KE, Walton SF, Innes A, Cash-Deans S, McCarthy JS. In vitro efficacy of moxidectin versus ivermectin against sarcoptes scabiei. Antimicrob Agents Chemother 2017; 61(8): e00381-17.
[http://dx.doi.org/10.1128/AAC.00381-17] [PMID: 28559258]
[108]
Huffam SE, Currie BJ. Ivermectin for Sarcoptes scabiei hyperinfestation. Int J Infect Dis 1998; 2(3): 152-4.
[http://dx.doi.org/10.1016/S1201-9712(98)90118-7] [PMID: 9531662]
[109]
Karthikeyan K. Treatment of scabies: newer perspectives. Postgrad Med J 2005; 81(951): 7-11.
[http://dx.doi.org/10.1136/pgmj.2003.018390] [PMID: 15640423]
[110]
Zawar V, Pawar M. Liquid nitrogen cryotherapy in the treatment of chronic, unresponsive nodular scabies. J Am Acad Dermatol 2017; 77(2): e43-4.
[http://dx.doi.org/10.1016/j.jaad.2017.03.034] [PMID: 28711102]
[111]
Leung AK, Wong BE, Chan PY, Cho HY. Pruritus in children. J R Soc Promot Health 1998; 118(5): 280-6.
[http://dx.doi.org/10.1177/146642409811800513] [PMID: 10076688]
[112]
Kearns TM, Speare R, Cheng AC, et al. Impact of an ivermectin mass drug administration on scabies prevalence in a remote Australian aboriginal community. PLoS Negl Trop Dis 2015; 9(10)e0004151
[http://dx.doi.org/10.1371/journal.pntd.0004151] [PMID: 26516764]
[113]
Romani L, Marks M, Sokana O, et al. Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial. Lancet Infect Dis 2019; 19(5): 510-8.
[http://dx.doi.org/10.1016/S1473-3099(18)30790-4]
[114]
Marks M, Toloka H, Baker C, et al. Randomized trial of community treatment with azithromycin and ivermectin mass drug administration for control of scabies and impetigo. Clin Infect Dis 2019; 68(6): 927-33.
[http://dx.doi.org/10.1093/cid/ciy574] [PMID: 29985978]


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VOLUME: 16
ISSUE: 1
Year: 2020
Page: [33 - 42]
Pages: 10
DOI: 10.2174/1573396315666190717114131

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