Title:The Role of Gut Microbiota in Antimicrobial Resistance: A Mini-Review
VOLUME: 18 ISSUE: 3
Author(s):Farzaneh Firoozeh and Mohammad Zibaei*
Affiliation:Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj
Keywords:Gut microbiota, antimicrobial resistance, AMR, MDR, resistome, gene transfer.
Abstract:In the current world, development and spread of antimicrobial resistance among bacteria have
been raised and antimicrobial-resistant bacteria are one of the most important health challenges. The antimicrobial
resistance genes can easily move and transfer among diverse bacterial species and strains. The human
gut microbiota consists of a dense microbial population including trillions of microorganisms. Recently,
studies have shown that the bacteria which make the major part of gut microbiota, harbor a variety of antimicrobial
resistance genes which are called gut resistome. The transfer of resistance genes from commensal bacteria
to gut-resident opportunistic bacteria may involve in the emergence of multi-drug resistant (MDR) bacteria.
Thus, the main aim of the current mini-review was to study the mechanisms of exchange of antimicrobial
resistance genes by commensal and opportunistic pathogenic bacteria in the human gut.
