The Role of Gut Microbiota in Antimicrobial Resistance: A Mini-Review

Author(s): Farzaneh Firoozeh, Mohammad Zibaei*

Journal Name: Anti-Infective Agents
Formerly Anti-Infective Agents in Medicinal Chemistry

Volume 18 , Issue 3 , 2020


DOI : 10.2174/2211352517666190716154013

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Graphical Abstract:


Abstract:

In the current world, development and spread of antimicrobial resistance among bacteria have been raised and antimicrobial-resistant bacteria are one of the most important health challenges. The antimicrobial resistance genes can easily move and transfer among diverse bacterial species and strains. The human gut microbiota consists of a dense microbial population including trillions of microorganisms. Recently, studies have shown that the bacteria which make the major part of gut microbiota, harbor a variety of antimicrobial resistance genes which are called gut resistome. The transfer of resistance genes from commensal bacteria to gut-resident opportunistic bacteria may involve in the emergence of multi-drug resistant (MDR) bacteria. Thus, the main aim of the current mini-review was to study the mechanisms of exchange of antimicrobial resistance genes by commensal and opportunistic pathogenic bacteria in the human gut.

Keywords: Gut microbiota, antimicrobial resistance, AMR, MDR, resistome, gene transfer.

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Article Details

VOLUME: 18
ISSUE: 3
Year: 2020
Published on: 16 July, 2019
Page: [201 - 206]
Pages: 6
DOI: 10.2174/2211352517666190716154013

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