Background: Osteoarthritis (OA) is a disease characterized by progressive degeneration,
joint hyperplasia, narrowing of joint spaces, and extracellular matrix metabolism. Recent studies have
shown that the pathogenesis of OA may be related to non-coding RNA, and its pathological mechanism
may be an effective way to reduce OA.
Objective: The purpose of this review was to investigate the recent progress of miRNA, long noncoding
RNA (lncRNA) and circular RNA (circRNA) in gene therapy of OA, discussing the effects of
this RNA on gene expression, inflammatory reaction, apoptosis and extracellular matrix in OA.
Methods: The following electronic databases were searched, including PubMed, EMBASE, Web of
Science, and the Cochrane Library, for published studies involving the miRNA, lncRNA, and circRNA
in OA. The outcomes included the gene expression, inflammatory reaction, apoptosis, and extracellular
Results and Discussion: With the development of technology, miRNA, lncRNA, and circRNA have
been found in many diseases. More importantly, recent studies have found that RNA interacts with
RNA-binding proteins to regulate gene transcription and protein translation, and is involved in various
pathological processes of OA, thus becoming a potential therapy for OA.
Conclusion: In this paper, we briefly introduced the role of miRNA, lncRNA, and circRNA in the occurrence
and development of OA and as a new target for gene therapy.