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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Research Article

Tuberculosis and Diabetes Mellitus in Northwest of Iran

Author(s): Mahdi Asghari Ozma, Jalil Rashedi*, Behroz Mahdavi Poor, Ali Vegari, Vahid Asgharzadeh, Hossein Samadi Kafil, Abdolhassan Kazemi, Leyla Sahebi and Mohammad Asgharzadeh

Volume 20, Issue 5, 2020

Page: [667 - 671] Pages: 5

DOI: 10.2174/1871526519666190715142100

Price: $65

Abstract

Background: Planning for control of tuberculosis would need to screen and identify individuals susceptible to TB. Due to the weakness of immune system in diabetic patients, it is more likely for them to reactivate latent TB infection. Regarding the increasing number of diabetics in the community, in this study efforts have been made to estimate the frequency of individuals who have tuberculosis and diabetes mellitus (TB-DM) simultaneously, as it could help making preventive decisions to reduce TB in this part of Iran.

Materials and Methods: In this study, 329 cases of confirmed TB patients were divided into two groups of diabetic and non-diabetic, then demographic information and clinical variables have been compared between the two groups.

Results: Among the examined subjects, 47 patients (14.29 %) had suffered from diabetes mellitus and tuberculosis. All of the DM patients had pulmonary tuberculosis and 87.23% of them were over the age of 50.

Conclusion: Majority of DM-TB patients were over 50 years of age and also more than half of them were women. So it seems that for DM women over the age of 50, to detect tuberculosis, screening tests such as PPD may be necessary.

Keywords: Tuberculosis, diabetes mellitus, association, Iran, microbial pathogen factors, HIV.

[1]
Daniel, T.M. The history of tuberculosis. Respir. Med., 2006, 100(11), 1862-1870.
[http://dx.doi.org/10.1016/j.rmed.2006.08.006] [PMID: 16949809]
[2]
Merza, M.A.; Farnia, P.; Salih, A.M.; Masjedi, M.R.; Velayati, A.A. First insight into the drug resistance pattern of Mycobacterium tuberculosis in Dohuk, Iraq: Using spoligotyping and MIRU-VNTR to characterize multidrug resistant strains. J. Infect. Public Health, 2011, 4(1), 41-47.
[http://dx.doi.org/10.1016/j.jiph.2010.11.002] [PMID: 21338958]
[3]
Rashedi, J.; Mahdavi Poor, B.; Rafi, A.; Asgharzadeh, M.; Abdolalizadeh, J.; Moaddab, S.R. Multidrug-resistant tuberculosis in north-west of Iran and Republic of Azerbaijan: A major public health concern for Iranian people. J. Res. Health Sci., 2015, 15(2), 101-103.
[PMID: 26175292]
[4]
Cegielski, J.P.; McMurray, D.N. The relationship between malnutrition and tuberculosis: Evidence from studies in humans and experimental animals. Int. J. Tuberc. Lung Dis., 2004, 8(3), 286-298.
[PMID: 15139466]
[5]
Rashedi, J.; Asgharzadeh, M.; Moaddab, S.R.; Sahebi, L.; Khalili, M.; Mazani, M.; Abdolalizadeh, J. Vitamin d receptor gene polymorphism and vitamin d plasma concentration: Correlation with susceptibility to tuberculosis. Adv. Pharm. Bull., 2014, 4(Suppl. 2), 607-611.
[PMID: 25671196]
[6]
Kamboj, M.; Sepkowitz, K.A. The risk of tuberculosis in patients with cancer. Clin. Infect. Dis., 2006, 42(11), 1592-1595.
[http://dx.doi.org/10.1086/503917] [PMID: 16652317]
[7]
Sharma, S.K.; Mohan, A.; Kadhiravan, T. HIV-TB co-infection: Epidemiology, diagnosis & management. Indian J. Med. Res., 2005, 121(4), 550-567.
[PMID: 15817963]
[8]
Magee, M.J.; Bloss, E.; Shin, S.S.; Contreras, C.; Huaman, H.A.; Ticona, J.C.; Bayona, J.; Bonilla, C.; Yagui, M.; Jave, O.; Cegielski, J.P. Clinical characteristics, drug resistance, and treatment outcomes among tuberculosis patients with diabetes in Peru. Int. J. Infect. Dis., 2013, 17(6), e404-e412.
[http://dx.doi.org/10.1016/j.ijid.2012.12.029] [PMID: 23434400]
[9]
Mi, F.; Tan, S.; Liang, L.; Harries, A.D.; Hinderaker, S.G.; Lin, Y.; Yue, W.; Chen, X.; Liang, B.; Gong, F.; Du, J. Diabetes mellitus and tuberculosis: Pattern of tuberculosis, two-month smear conversion and treatment outcomes in Guangzhou, China. Trop. Med. Int. Health, 2013, 18(11), 1379-1385.
[http://dx.doi.org/10.1111/tmi.12198] [PMID: 24112411]
[10]
Baker, M.A.; Lin, H-H.; Chang, H-Y.; Murray, M.B. The risk of tuberculosis disease among persons with diabetes mellitus: A prospective cohort study. Clin. Infect. Dis., 2012, 54(6), 818-825.
[http://dx.doi.org/10.1093/cid/cir939] [PMID: 22238171]
[11]
Dooley, K.E.; Chaisson, R.E. Tuberculosis and diabetes mellitus: Convergence of two epidemics. Lancet Infect. Dis., 2009, 9(12), 737-746.
[http://dx.doi.org/10.1016/S1473-3099(09)70282-8] [PMID: 19926034]
[12]
Jeon, C.Y.; Murray, M.B. Diabetes mellitus increases the risk of active tuberculosis: A systematic review of 13 observational studies. PLoS Med., 2008, 5(7)e152
[http://dx.doi.org/10.1371/journal.pmed.0050152] [PMID: 18630984]
[13]
Wang, Q.; Ma, A.; Han, X.; Zhao, S.; Cai, J.; Ma, Y.; Zhao, J.; Wang, Y.; Dong, H.; Zhao, Z.; Wei, L.; Yu, T.; Chen, P.; Schouten, E.G.; Kok, F.J.; Kapur, A. Prevalence of type 2 diabetes among newly detected pulmonary tuberculosis patients in China: A community based cohort study. PLoS One, 2013, 8(12)e82660
[http://dx.doi.org/10.1371/journal.pone.0082660] [PMID: 24367535]
[14]
Esteghamati, A.; Gouya, M.M.; Abbasi, M.; Delavari, A.; Alikhani, S.; Alaedini, F.; Safaie, A.; Forouzanfar, M.; Gregg, E.W. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran. Diabetes Care, 2008, 31(1), 96-98.
[http://dx.doi.org/10.2337/dc07-0959] [PMID: 17921357]
[15]
Jasmer, R.M.; Roemer, M.; Hamilton, J.; Bunter, J.; Braden, C.R.; Shinnick, T.M.; Desmond, E.P. A prospective, multicenter study of laboratory cross-contamination of Mycobacterium tuberculosis cultures. Emerg. Infect. Dis., 2002, 8(11), 1260-1263.
[http://dx.doi.org/10.3201/eid0811.020298] [PMID: 12453353]
[16]
Restrepo, B.I.; Fisher-Hoch, S.P.; Pino, P.A.; Salinas, A.; Rahbar, M.H.; Mora, F.; Cortes-Penfield, N.; McCormick, J.B. Tuberculosis in poorly controlled type 2 diabetes: altered cytokine expression in peripheral white blood cells. Clin. Infect. Dis., 2008, 47(5), 634-641.
[http://dx.doi.org/10.1086/590565] [PMID: 18652554]
[17]
Abdoli, S.; Ashktorab, T.; Ahmadi, F.; Parvizy, S.; Dunning, T. Religion, faith and the empowerment process: stories of Iranian people with diabetes. Int. J. Nurs. Pract., 2011, 17(3), 289-298.
[http://dx.doi.org/10.1111/j.1440-172X.2011.01937.x] [PMID: 21605270]
[18]
Ponce-De-Leon, A. Garcia-Garcia Md, Mde.L.; Garcia-Sancho, M.C.; Gomez-Perez, F.J.; Valdespino-Gomez, J.L.; Olaiz-Fernandez, G.; Rojas, R.; Ferreyra-Reyes, L.; Cano-Arellano, B.; Bobadilla, M.; Small, P.M.; Sifuentes-Osornio, J. Tuberculosis and diabetes in southern Mexico. Diabetes Care, 2004, 27(7), 1584-1590.
[http://dx.doi.org/10.2337/diacare.27.7.1584] [PMID: 15220232]
[19]
Stevenson, C.R.; Forouhi, N.G.; Roglic, G.; Williams, B.G.; Lauer, J.A.; Dye, C.; Unwin, N. Diabetes and tuberculosis: The impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health, 2007, 7(1), 234.
[http://dx.doi.org/10.1186/1471-2458-7-234] [PMID: 17822539]
[20]
Montoya-Rosales, A.; Castro-Garcia, P.; Torres-Juarez, F.; Enciso-Moreno, J.A.; Rivas-Santiago, B. Glucose levels affect LL-37 expression in monocyte-derived macrophages altering the Mycobacterium tuberculosis intracellular growth control. Microb. Pathog., 2016, 97, 148-153.
[http://dx.doi.org/10.1016/j.micpath.2016.06.002] [PMID: 27263098]
[21]
Stalenhoef, J.E.; Alisjahbana, B.; Nelwan, E.J.; van der Ven-Jongekrijg, J.; Ottenhoff, T.H.; van der Meer, J.W.; Nelwan, R.H.; Netea, M.G.; van Crevel, R. The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus. Eur. J. Clin. Microbiol. Infect. Dis., 2008, 27(2), 97-103.
[http://dx.doi.org/10.1007/s10096-007-0395-0] [PMID: 17962984]
[22]
Pitocco, D.; Fuso, L.; Conte, E.G.; Zaccardi, F.; Condoluci, C.; Scavone, G.; Incalzi, R.A.; Ghirlanda, G. The diabetic lung--a new target organ? Rev. Diabet. Stud., 2012, 9(1), 23-35.
[http://dx.doi.org/10.1900/RDS.2012.9.23] [PMID: 22972442]
[23]
Haghdoost, A.A.; Mostafavi, E.; Mirzazadeh, A.; Navadeh, S.; Feizzadeh, A.; Fahimfar, N. Modelling of HIV/AIDS in Iran up to 2014. J. AIDS HIV Res., 2011, 3(12), 231-239.
[http://dx.doi.org/10.5897/JAHR11.030]
[24]
Haghdoost, A.A.; Rezazadeh-Kermani, M.; Sadghirad, B.; Baradaran, H.R. Prevalence of type 2 diabetes in the Islamic Republic of Iran: Systematic review and meta-analysis. East. Mediterr. Health J., 2009, 15(3), 591-599.
[http://dx.doi.org/10.26719/2009.15.3.591] [PMID: 19731775]
[25]
World Health Organization. Global tuberculosis report 2015.WHO/HTM/TB/2015. 22; WHO: Geneva, Switzerland, 2015.
[26]
Baghaei, P.; Tabarsi, P.; Javanmard, P.; Farnia, P.; Marjani, M.; Moniri, A.; Masjedi, M.R.; Velayati, A.A. Impact of diabetes mellitus on tuberculosis drug resistance in new cases of tuberculosis. J. Glob. Antimicrob. Resist., 2016, 4, 1-4.
[http://dx.doi.org/10.1016/j.jgar.2015.11.006] [PMID: 27436384]
[27]
Asgharzadeh, M.; Kafil, H.S.; Roudsary, A.A.; Hanifi, G.R. Tuberculosis transmission in Northwest of Iran: Using MIRU-VNTR, ETR-VNTR and IS6110-RFLP methods. Infect. Genet. Evol., 2011, 11(1), 124-131.
[http://dx.doi.org/10.1016/j.meegid.2010.09.013] [PMID: 20951237]
[28]
Maguire, H.; Dale, J.W.; McHugh, T.D.; Butcher, P.D.; Gillespie, S.H.; Costetsos, A.; Al-Ghusein, H.; Holland, R.; Dickens, A.; Marston, L.; Wilson, P.; Pitman, R.; Strachan, D.; Drobniewski, F.A.; Banerjee, D.K. Molecular epidemiology of tuberculosis in London 1995-7 showing low rate of active transmission. Thorax, 2002, 57(7), 617-622.
[http://dx.doi.org/10.1136/thorax.57.7.617] [PMID: 12096206]
[29]
Gutiérrez, M.C.; Vincent, V.; Aubert, D.; Bizet, J.; Gaillot, O.; Lebrun, L.; Le Pendeven, C.; Le Pennec, M.P.; Mathieu, D.; Offredo, C.; Pangon, B.; Pierre-Audigier, C. Molecular fingerprinting of Mycobacterium tuberculosis and risk factors for tuberculosis transmission in Paris, France, and surrounding area. J. Clin. Microbiol., 1998, 36(2), 486-492.
[PMID: 9466764]
[30]
Dunstan, D.W.; Zimmet, P.Z.; Welborn, T.A.; De Courten, M.P.; Cameron, A.J.; Sicree, R.A.; Dwyer, T.; Colagiuri, S.; Jolley, D.; Knuiman, M.; Atkins, R.; Shaw, J.E. The rising prevalence of diabetes and impaired glucose tolerance: The Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care, 2002, 25(5), 829-834.
[http://dx.doi.org/10.2337/diacare.25.5.829] [PMID: 11978676]
[31]
Pourostadi, M.; Rashedi, J.; Mahdavi Poor, B.; Samadi Kafil, H.; Shirazi, S.; Asgharzadeh, M. Molecular Diversity of Mycobacterium tuberculosis Strains in Northwestern Iran. Jundishapur J. Microbiol., 2016, 9(9)e35520
[http://dx.doi.org/10.5812/jjm.35520] [PMID: 27800145]

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