Aim: To present an insulinoma case with post-prandial hypoglycemic symptoms associated
with glucose inducible endogenous hyperinsulinemia.
Case: A 52-year-old female patient was evaluated for hypoglycemic symptoms especially those occuring
within 3 hours after consuming sugary foods. These symptoms were persistent for a year and a half.
She was diagnosed with reactive (post-prandial) syndrome and followed a recommended diet and was
given acarbose but there was no improvement. The results suggested post-prandial endogenous hyperinsulinemia
related hypoglycemia. Multiphasic computerized tomography revealed an 11x15x12 mm size
mass lesion, anteriorly in the head and uncinate process of the pancreas and then the patients were
treated surgically with pancreatic enucleation and cured.
Conclusion: Distinguishing post-prandial syndrome by careful history and clinical evaluation in patients
with postprandial symptoms is of great importance in terms of cost-effectivity. However, it should
not be forgotten that although organic pathologies are mostly presented with fasting hypoglycemia, they
may also cause post-prandial symptoms. Severity and progression of the symptoms that point to neuroglycopenia
is important, and in this condition the most convenient clinical approach to the patient
should be performed with careful and appropriate assessment steps.