Organophosphate (OP) pesticides are extremely poisonous and they affect the glucose
breakdown in numerous and mechanism. There are higher evidence of stimulating diabetes mellitus
through OP pesticides especially the type II diabetes. The upsurge in the level of glucose (hyperglycemia),
and insulin resistance along with their related outcomes are discussed in this review. The data related
to investigational and clinical techniques endorse a connection amid such molecular mechanism
and compounds of OPs. Numerous studies conducted till March 2018 have reported OP’ exposures and
diabetes-related outcomes. The acute and chronic exposure in case of these insecticides and diabetesrelated
outcomes are defined in this study. Initially, it was declared that OPs prompt to hyperglycemia.
Then, a high association of glucose in blood beside insulin was found out. The affirmation from some
clinical as well as investigational studies supported a connection amid exposure to OP and diabetes, yet
in maximum number of instances, non-specific diabetes occurs.
Keywords: Diabetes mellitus, glucose metabolism, organophosphates, pesticides, type-II diabetes mellitus.
Campbell A, Chapman M. Handbook of poisoning in dogs and cats. 2008.
Singh M, Sandhir R, Kiran R. Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides 2006.
Pinget M, Boullu-Sanchis S. Physiological basis of insulin secretion abnormalities 2002.
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