Background: Kisspeptin is one of the most potent stimulators of GnRH secretion and
consequent gonadotropin release from the anterior pituitary. Kisspeptin is considered critical in
regulating reproductive function in relation to metabolic cues. Reproductive function is gated by
the energy reserves of the individual. Conditions of energy insufficiency, such as Anorexia Nervosa,
often disturb reproductive function and fertility.
Objective: The aim of this research was to investigate similar or comparable hormonal patterns in
kisspeptin mechanics using computational methodology tools.
Methods: Twenty-two females with typical or atypical anorexia nervosa and fifteen control females,
were recruited from the Center for Adolescent Medicine of the University of Athens. Serum
levels of Prolactin (PRL), 17-Hydroxy-Progesterone (17OHPR), Free Triiodothyronine (FT3), Triiodothyronine
(T3), Free Thyroxine (FT4), Thyroid Stimulating Hormone (TSH), Luteinizing
Hormone (LH), Follicle Stimulating Hormone (FSH) and Estradiol (E2) were measured in patients
and controls. Data were modelled computationally in order to find similar or comparable patterns
between control and anorexic participants, with respect to kisspeptin.
Results: Kisspeptin manifested symmetrical regression plots between controls and anorexics with
respect to 17OHPR, LH and FSH, as well as a threshold pattern among controls, typical and atypical
Conclusion: Kisspeptin seems to participate in the anorexic hormonal milieu through threshold or